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In vivo effects of interferon-Γ and anti-interferon-Γ antibody on the experimentally induced lichenoid tissue reaction

dc.contributor.authorShiohara, T.en_US
dc.contributor.authorNickoloff, Brian J.en_US
dc.contributor.authorMoriya, N.en_US
dc.contributor.authorGotoh, C.en_US
dc.contributor.authorNagashima, M.en_US
dc.date.accessioned2010-06-01T21:31:29Z
dc.date.available2010-06-01T21:31:29Z
dc.date.issued1988-08en_US
dc.identifier.citationSHIOHARA, T.; NICKOLOFF, B. J.; MORIYA, N.; GOTOH, C.; NAGASHIMA, M. (1988). "In vivo effects of interferon-Γ and anti-interferon-Γ antibody on the experimentally induced lichenoid tissue reaction." British Journal of Dermatology 119(2): 199-206. <http://hdl.handle.net/2027.42/74579>en_US
dc.identifier.issn0007-0963en_US
dc.identifier.issn1365-2133en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74579
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3139020&dopt=citationen_US
dc.description.abstractWe investigated the in vivo effect of recombinant interferon-Γ (IFN-Γ) and tumour necrosis factor Α (TNF-Α) treatment of mice on the development of the delayed-type hypersensitivity (DTH) reaction and lichenoid tissue reaction (LTR) following the local injection of cloned autoreactive T cells. Both the DTH reaction and the LTR were significantly enhanced by pre-treatment with IFN-Γ, but not with TNF-Ã. Induction of class II MHC antigens on keratinocytes was not essential for the enhancement by IFN-Γ. Administration of anti-IFN-Γ antibody reduced the DTH reaction and LTR, although complete inhibition was not observed with our treatment regimen. The ability of IFN-Γ to increase the number of the cloned T cells invading the epidermis in vivo , is in keeping with our previous observation that IFN-Γ treatment of cultured keratinocytes markedly increased the adherence reaction between T cells and keratinocytes in vitro.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1988 British Association of Dermatologistsen_US
dc.titleIn vivo effects of interferon-Γ and anti-interferon-Γ antibody on the experimentally induced lichenoid tissue reactionen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDermatologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Departments of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Dermatology, Kyorin University School of Medicine, Tokyo, Japanen_US
dc.identifier.pmid3139020en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74579/1/j.1365-2133.1988.tb03202.x.pdf
dc.identifier.doi10.1111/j.1365-2133.1988.tb03202.xen_US
dc.identifier.sourceBritish Journal of Dermatologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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