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Diabetes and reactivity of isolated human saphenous vein
dc.contributor.authorCardwell, Robert J.en_US
dc.contributor.authorWebb, R. Clintonen_US
dc.date.accessioned2010-06-01T21:35:21Z
dc.date.available2010-06-01T21:35:21Z
dc.date.issued1984-12en_US
dc.identifier.citationCardwell, Robert J.; Webb, R. Clinton (1984). "Diabetes and reactivity of isolated human saphenous vein." Clinical Physiology 4(6): 509-517. <http://hdl.handle.net/2027.42/74640>en_US
dc.identifier.issn0144-5979en_US
dc.identifier.issn1365-2281en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74640
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6097393&dopt=citationen_US
dc.description.abstractHelical strips of saphenous veins from diabetic ( n =8) and non-diabetic ( n = 18) humans were studied in vivo for their responsiveness to several vasoactive agents. Following application of passive force (˜20·0 mN), venous strips from non-diabetic humans often developed spontaneous phasic contractile activity (12 out of 18 patients; 2–5 contractions/min). These intrinsic changes in force were seen in venous strips from only one diabetic patient. The phasic contractions were not altered by treatment with phentolamine, whereas the calcium channel blocker, D-600, and calcium-free solution (1·0 mM EGTA) inhibited the phasic contractions. Saphenous veins from diabetic patients developed less maximal, active tension in response to norepinephrine than those from non-diabetic patients. Contractile responses to serotonin, angiotensin II, and elevated potassium concentration in saphenous veins from diabetic patients were not different from those in veins from non-diabetic patients. These observations demonstrate attenuated development of active tension in response to alpha-adrenergic receptor activation and reduced spontaneous contractile activity in venous smooth muscle from diabetic patients.en_US
dc.format.extent541373 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1984 Scandinavian Society of Clinical Physiologyen_US
dc.titleDiabetes and reactivity of isolated human saphenous veinen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan Medical School, Ann Arbor. Michigan 48109, U.S.Aen_US
dc.identifier.pmid6097393en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74640/1/j.1475-097X.1984.tb00136.x.pdf
dc.identifier.doi10.1111/j.1475-097X.1984.tb00136.xen_US
dc.identifier.sourceClinical Physiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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