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Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model
dc.contributor.authorWells, Virginia D.en_US
dc.contributor.authorMunro, Cindy L.en_US
dc.contributor.authorSulavik, Mark C.en_US
dc.contributor.authorClewell, Don B.en_US
dc.contributor.authorMacrina, Francis L.en_US
dc.date.accessioned2010-06-01T21:36:21Z
dc.date.available2010-06-01T21:36:21Z
dc.date.issued1993-09en_US
dc.identifier.citationWells, Virginia D.; Munro, Cindy L.; Sulavik, Mark C.; Clewell, Don B.; Macrina, Francis L. (1993). "Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model." FEMS Microbiology Letters 112(3): 301-306. <http://hdl.handle.net/2027.42/74656>en_US
dc.identifier.issn0378-1097en_US
dc.identifier.issn1574-6968en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74656
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8224794&dopt=citationen_US
dc.description.abstractStreptococcus gordonii , a member of the human indigenous oral microflora, colonizes smooth tooth surfaces and contributes to dental plaque formation. Although it is not recognized as being a cariogenic pathogen, it may cause endocarditis following invasion of the bloodstream. Using allelic exchange mutagenesis, we have constructed a mutant of S. gordonii (Challis) which is defective in its single functional glucosyltransferase gene and, hence, is unable to synthesize glucan exopolymers from sucrose. When examined in a rat endocarditis model, the sucrose-grown mutant did not differ significantly from S. gordonii wild-type, suggesting that glucan polymers did not contribute to infectivity. This result was in striking contrast to that previously observed with a polymer-defective S. mutans mutant.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1993 Federation of European Microbiological Societiesen_US
dc.subject.otherEndocarditisen_US
dc.subject.otherStreptococcus Gordoniien_US
dc.subject.otherGlucosyltransferaseen_US
dc.titleInfectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis modelen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid8224794en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74656/1/j.1574-6968.1993.tb06466.x.pdf
dc.identifier.doi10.1111/j.1574-6968.1993.tb06466.xen_US
dc.identifier.sourceFEMS Microbiology Lettersen_US
dc.identifier.citedreferenceKilian, M., Mikkelsen, L. and Henrichsen, J. ( 1989 ) Int. J. Syst. Bacteriol., 39, 471 – 484.en_US
dc.identifier.citedreferenceGuntheroth, W.G. ( 1984 ) Am. J. Cardiol., 54, 797 – 801.en_US
dc.identifier.citedreferenceEverett, E.D. and Hirschmann, J.V. ( 1977 ) Medicine, 56, 61 – 77.en_US
dc.identifier.citedreferenceTardif, G., Sulavik, M.C., Jones, G.W. and Clewell, D.B. ( 1989 ) Infect. Immun., 57, 3945 – 3948.en_US
dc.identifier.citedreferenceSulavik, M.C., Tardif, G. and Clewell, D.B. ( 1992 ) J. Bacteriol., 174, 3577 – 3586.en_US
dc.identifier.citedreferenceUeda, S., Shiroza, T. and Kuramitsu, H.K. ( 1988 ) Gene, 69, 101 – 109.en_US
dc.identifier.citedreferenceShiroza, T., Ueda, S. and Kuramitsu, H.K. ( 1987 ) J. Bacteriol., 169, 4263 – 4270.en_US
dc.identifier.citedreferenceHonda, O., Kato, C. and Kuramitsu, H.K. ( 1990 ) J. Gen. Microbiol., 136, 2099 – 2105.en_US
dc.identifier.citedreferenceSchroeder, V.A., Michalek, S.M. and Macrina, F.L. ( 1989 ) Infect. Immun., 57, 3560 – 3569.en_US
dc.identifier.citedreferenceMunro, C., Michalek, S.M. and Macrina, F.L. ( 1991 ) Infect. Immun., 59, 2316 – 2323.en_US
dc.identifier.citedreferenceLoesche, W.J. ( 1986 ) Microbiol. Rev., 50, 353 – 380.en_US
dc.identifier.citedreferenceHamada, S. and Slade, H.D. ( 1980 ) Microbiol. Rev., 44, 331 – 384.en_US
dc.identifier.citedreferenceMacrina, F.L., Dertzbaugh, M.T., Halula, M.C., Krah, E.R. and Jones, K.R. ( 1990 ) CRC Crit. Rev. in Oral Biol. and Med., 1, 207 – 227.en_US
dc.identifier.citedreferenceGarrison, P.K. and Freedman, L.R. ( 1970 ) Yale J. Biol. Med., 42, 394 – 410.en_US
dc.identifier.citedreferenceGarrison, P.G. and Freedman, L.R. ( 1971 ) Yale J. Biology, 44, 206 – 213.en_US
dc.identifier.citedreferenceDurack, D.T. and Beeson, P.B. ( 1972 ) Br. J. Exp. Pathol., 53, 44 – 49.en_US
dc.identifier.citedreferenceAngrist, A. and Oka, M. ( 1963 ) JAMA, 183, 249 – 252.en_US
dc.identifier.citedreferenceScheld, W.M., Valone, J.A. and Sande, M.A. ( 1978 ) J. Clin. Invest., 61, 1394 – 1404.en_US
dc.identifier.citedreferenceRamirez-Ronda, C. ( 1978 ) J. Clin. Invest., 62, 805 – 814.en_US
dc.identifier.citedreferenceMunro, C.L. and Macrina, F.L. ( 1993 ) Mol. Microbiol., 8, 133 – 142.en_US
dc.identifier.citedreferenceMacrina, F.L., Wood, P.H. and Jones, K.R. ( 1980 ) Infect. Immun., 28, 692 – 699.en_US
dc.identifier.citedreferenceSantoro, J. and Levison, M.E. ( 1978 ) Infect. Immun., 19, 915 – 918.en_US
dc.identifier.citedreferenceBayliss, R., Clark, C., Oakley, C., Somerville, W., Whitfield, A. and Young, S. ( 1983 ) Br. Heart. Journal, 50, 513 – 519.en_US
dc.identifier.citedreferenceVan der Meer, J.T., Van Vianen, W., Hu, E., Van Leeuwen, W.B., Valkenburg, H.A., Thompson, J. and Michel, M.F. ( 1991 ) Eur. J. Clin. Microbiol. Infect. Dis., 10, 728 – 734.en_US
dc.identifier.citedreferenceCoykendall, A. ( 1989 ) Clin. Microbiol. Rev., 2, 315 – 328.en_US
dc.identifier.citedreferenceYoungman, P. ( 1987 ) In Plasmids, A Practical Approach. Hardy, K., Ed ) pp 79 – 103 ILR Press, Oxford.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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