Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model
dc.contributor.author | Wells, Virginia D. | en_US |
dc.contributor.author | Munro, Cindy L. | en_US |
dc.contributor.author | Sulavik, Mark C. | en_US |
dc.contributor.author | Clewell, Don B. | en_US |
dc.contributor.author | Macrina, Francis L. | en_US |
dc.date.accessioned | 2010-06-01T21:36:21Z | |
dc.date.available | 2010-06-01T21:36:21Z | |
dc.date.issued | 1993-09 | en_US |
dc.identifier.citation | Wells, Virginia D.; Munro, Cindy L.; Sulavik, Mark C.; Clewell, Don B.; Macrina, Francis L. (1993). "Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model." FEMS Microbiology Letters 112(3): 301-306. <http://hdl.handle.net/2027.42/74656> | en_US |
dc.identifier.issn | 0378-1097 | en_US |
dc.identifier.issn | 1574-6968 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74656 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8224794&dopt=citation | en_US |
dc.description.abstract | Streptococcus gordonii , a member of the human indigenous oral microflora, colonizes smooth tooth surfaces and contributes to dental plaque formation. Although it is not recognized as being a cariogenic pathogen, it may cause endocarditis following invasion of the bloodstream. Using allelic exchange mutagenesis, we have constructed a mutant of S. gordonii (Challis) which is defective in its single functional glucosyltransferase gene and, hence, is unable to synthesize glucan exopolymers from sucrose. When examined in a rat endocarditis model, the sucrose-grown mutant did not differ significantly from S. gordonii wild-type, suggesting that glucan polymers did not contribute to infectivity. This result was in striking contrast to that previously observed with a polymer-defective S. mutans mutant. | en_US |
dc.format.extent | 376016 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1993 Federation of European Microbiological Societies | en_US |
dc.subject.other | Endocarditis | en_US |
dc.subject.other | Streptococcus Gordonii | en_US |
dc.subject.other | Glucosyltransferase | en_US |
dc.title | Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 8224794 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74656/1/j.1574-6968.1993.tb06466.x.pdf | |
dc.identifier.doi | 10.1111/j.1574-6968.1993.tb06466.x | en_US |
dc.identifier.source | FEMS Microbiology Letters | en_US |
dc.identifier.citedreference | Kilian, M., Mikkelsen, L. and Henrichsen, J. ( 1989 ) Int. J. Syst. Bacteriol., 39, 471 – 484. | en_US |
dc.identifier.citedreference | Guntheroth, W.G. ( 1984 ) Am. J. Cardiol., 54, 797 – 801. | en_US |
dc.identifier.citedreference | Everett, E.D. and Hirschmann, J.V. ( 1977 ) Medicine, 56, 61 – 77. | en_US |
dc.identifier.citedreference | Tardif, G., Sulavik, M.C., Jones, G.W. and Clewell, D.B. ( 1989 ) Infect. Immun., 57, 3945 – 3948. | en_US |
dc.identifier.citedreference | Sulavik, M.C., Tardif, G. and Clewell, D.B. ( 1992 ) J. Bacteriol., 174, 3577 – 3586. | en_US |
dc.identifier.citedreference | Ueda, S., Shiroza, T. and Kuramitsu, H.K. ( 1988 ) Gene, 69, 101 – 109. | en_US |
dc.identifier.citedreference | Shiroza, T., Ueda, S. and Kuramitsu, H.K. ( 1987 ) J. Bacteriol., 169, 4263 – 4270. | en_US |
dc.identifier.citedreference | Honda, O., Kato, C. and Kuramitsu, H.K. ( 1990 ) J. Gen. Microbiol., 136, 2099 – 2105. | en_US |
dc.identifier.citedreference | Schroeder, V.A., Michalek, S.M. and Macrina, F.L. ( 1989 ) Infect. Immun., 57, 3560 – 3569. | en_US |
dc.identifier.citedreference | Munro, C., Michalek, S.M. and Macrina, F.L. ( 1991 ) Infect. Immun., 59, 2316 – 2323. | en_US |
dc.identifier.citedreference | Loesche, W.J. ( 1986 ) Microbiol. Rev., 50, 353 – 380. | en_US |
dc.identifier.citedreference | Hamada, S. and Slade, H.D. ( 1980 ) Microbiol. Rev., 44, 331 – 384. | en_US |
dc.identifier.citedreference | Macrina, F.L., Dertzbaugh, M.T., Halula, M.C., Krah, E.R. and Jones, K.R. ( 1990 ) CRC Crit. Rev. in Oral Biol. and Med., 1, 207 – 227. | en_US |
dc.identifier.citedreference | Garrison, P.K. and Freedman, L.R. ( 1970 ) Yale J. Biol. Med., 42, 394 – 410. | en_US |
dc.identifier.citedreference | Garrison, P.G. and Freedman, L.R. ( 1971 ) Yale J. Biology, 44, 206 – 213. | en_US |
dc.identifier.citedreference | Durack, D.T. and Beeson, P.B. ( 1972 ) Br. J. Exp. Pathol., 53, 44 – 49. | en_US |
dc.identifier.citedreference | Angrist, A. and Oka, M. ( 1963 ) JAMA, 183, 249 – 252. | en_US |
dc.identifier.citedreference | Scheld, W.M., Valone, J.A. and Sande, M.A. ( 1978 ) J. Clin. Invest., 61, 1394 – 1404. | en_US |
dc.identifier.citedreference | Ramirez-Ronda, C. ( 1978 ) J. Clin. Invest., 62, 805 – 814. | en_US |
dc.identifier.citedreference | Munro, C.L. and Macrina, F.L. ( 1993 ) Mol. Microbiol., 8, 133 – 142. | en_US |
dc.identifier.citedreference | Macrina, F.L., Wood, P.H. and Jones, K.R. ( 1980 ) Infect. Immun., 28, 692 – 699. | en_US |
dc.identifier.citedreference | Santoro, J. and Levison, M.E. ( 1978 ) Infect. Immun., 19, 915 – 918. | en_US |
dc.identifier.citedreference | Bayliss, R., Clark, C., Oakley, C., Somerville, W., Whitfield, A. and Young, S. ( 1983 ) Br. Heart. Journal, 50, 513 – 519. | en_US |
dc.identifier.citedreference | Van der Meer, J.T., Van Vianen, W., Hu, E., Van Leeuwen, W.B., Valkenburg, H.A., Thompson, J. and Michel, M.F. ( 1991 ) Eur. J. Clin. Microbiol. Infect. Dis., 10, 728 – 734. | en_US |
dc.identifier.citedreference | Coykendall, A. ( 1989 ) Clin. Microbiol. Rev., 2, 315 – 328. | en_US |
dc.identifier.citedreference | Youngman, P. ( 1987 ) In Plasmids, A Practical Approach. Hardy, K., Ed ) pp 79 – 103 ILR Press, Oxford. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.