Refinements in Mathematical Models to Predict Aneurysm Growth and Rupture
dc.contributor.author | Berguer, Ramon | en_US |
dc.contributor.author | Bull, Joseph L. | en_US |
dc.contributor.author | Khanafer, Khalil | en_US |
dc.date.accessioned | 2010-06-01T21:38:11Z | |
dc.date.available | 2010-06-01T21:38:11Z | |
dc.date.issued | 2006-11 | en_US |
dc.identifier.citation | BERGUER, RAMON; BULL, JOSEPH L . ; KHANAFER, KHALIL (2006). "Refinements in Mathematical Models to Predict Aneurysm Growth and Rupture." Annals of the New York Academy of Sciences 1085(1 The Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology ): 110-116. <http://hdl.handle.net/2027.42/74685> | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.issn | 1749-6632 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74685 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17182927&dopt=citation | en_US |
dc.description.abstract | The growth of aneurysms and eventually their likelihood of rupture depend on the determination of the stress and strain within the aneurysm wall and the exact reproduction of its geometry. A numerical model is developed to analyze pulsatile flow in abdominal aortic aneurysm (AAA) models using real physiological resting and exercise waveforms. Both laminar and turbulent flows are considered. Interesting features of the flow field resulting from using realistic physiological waveforms are obtained for various parameters using finite element methods. Such parameters include Reynolds number, size of the aneurysm (D d), and flexibility of the aneurysm wall. The effect of non-Newtonian behavior of blood on hemodynamic stresses is compared with Newtonian behavior, and the non-Newtonian effects are demonstrated to be significant in realistic flow situations. Our results show that maximum turbulent fluid shear stress occurs at the distal end of the AAA model. Furthermore, turbulence is found to have a significant effect on the pressure distribution along AAA wall for both physiological waveforms. Related experimental work in which a bench top aneurysm model is developed is also discussed. The experimental model provides a platform to validate the numerical model. This work is part of our ongoing development of a patient-specific tool to guide clinician decision making and to elucidate the contribution of blood flow-induced stresses to aneurysm growth and eventual rupture. These studies indicate that accurately modeling the physiologic features of real aneurysms and blood is paramount to achieving our goal. | en_US |
dc.format.extent | 250994 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.rights | 2006 New York Academy of Sciences | en_US |
dc.subject.other | Aneurysm | en_US |
dc.subject.other | Laminar | en_US |
dc.subject.other | Mechanical Hinge | en_US |
dc.subject.other | Non-Newtonian | en_US |
dc.subject.other | Turbulent Flow | en_US |
dc.title | Refinements in Mathematical Models to Predict Aneurysm Growth and Rupture | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Vascular Mechanics Laboratory, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Vascular Mechanics Laboratory, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 17182927 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74685/1/annals.1383.033.pdf | |
dc.identifier.doi | 10.1196/annals.1383.033 | en_US |
dc.identifier.source | Annals of the New York Academy of Sciences | en_US |
dc.identifier.citedreference | Wainess, R.M., J.B. Dimick, J.A. Cowan, et al. 2004. Epidemiology of surgically treated abdominal aortic aneurysms in the United States. Vascular 12: 218 224. | en_US |
dc.identifier.citedreference | 2. National Hospital Discharge Survey. 2001. Annual Summary with Detailed Diagnosis and Procedure Data. Hyattsville, MD: National Center for Health Statistics; June 2004. | en_US |
dc.identifier.citedreference | Wassef, M., B.T. Baxter, R.L. Chisholm, et al. 2001. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J. Vasc. Surg. 34: 730 738. | en_US |
dc.identifier.citedreference | Budwig, R., D. Elger, H. Hooper & J. Slippy. 1993. Steady flow in abdominal aortic aneurysm models. ASME J. Biomech. Eng. 115: 419 423. | en_US |
dc.identifier.citedreference | Asbury, C.L., J.W. Rwberti, E.I. Bluth & R.A. Peattie. 1995. Experimental investigation of steady flow in rigid models of abdominal aortic aneurysm. Annals. Biomed. Eng. 23: 29 39. | en_US |
dc.identifier.citedreference | Fukushima, T., T. Matsuzawa & T. Homma. 1998. Visualization and finite element analysis of pulsatile flow in models of the abdominal aortic aneurysm. Biorheology 26: 109 130. | en_US |
dc.identifier.citedreference | Mills, C., I. Gabe, J. Gault, et al. 1970. Pressure-flow relationships and vascular impedance in man, Cardiovasc. Res. 4: 405 417. | en_US |
dc.identifier.citedreference | Pedersen, E., H. Sung, A. Burlson & A. Yoganathan. 1993. Two-dimensional velocity measurements in a pulsatile flow model of the normal abdominal aorta simulating different hemodynamic conditions. J. Biomech. 26: 1237 1247. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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