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Photodynamic Characterization and In Vitro Application of Methylene Blue-containing Nanoparticle Platforms ¶

dc.contributor.authorKopelman, Raoulen_US
dc.contributor.authorPhilbert, Martin A.en_US
dc.contributor.authorTang, Weien_US
dc.contributor.authorXu, Haoen_US
dc.date.accessioned2010-06-01T21:40:08Z
dc.date.available2010-06-01T21:40:08Z
dc.date.issued2005-03en_US
dc.identifier.citationTang, Wei; Xu, Hao; Kopelman, Raoul; Philbert, Martin A. (2005). "Photodynamic Characterization and In Vitro Application of Methylene Blue-containing Nanoparticle Platforms ¶ ." Photochemistry and Photobiology 81(2): 242-249. <http://hdl.handle.net/2027.42/74716>en_US
dc.identifier.issn0031-8655en_US
dc.identifier.issn1751-1097en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74716
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15595888&dopt=citationen_US
dc.description.abstractThis article presents the development and characterization of nanoparticles loaded with methylene blue (MB), which are designed to be administered to tumor cells externally and deliver singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT), i.e. cell kill via oxidative stress to the membrane. We demonstrated the encapsulation of MB, a photosensitizer (PS), in three types of sub-200 nm nanoparticles, composed of polyacrylamide, sol-gel silica and organically modified silicate (ORMOSIL), respectively. Induced by light irradiation, the entrapped MB generated 1 O 2 ), and the produced 1 O 2 was measured quantitatively with anthracene-9, 10-dipropionic acid, disodium salt, to compare the effects of different matrices on 1 O 2 delivery. Among these three different kinds of nanoparticles, the polyacrylamide nanoparticles showed the most efficient delivery of 1 O 2 but its loading of MB was low. In contrast, the sol-gel nanoparticles had the best MB loading but the least efficient 1 O 2 delivery. In addition to investigating the matrix effects, a preliminary in vitro PDT study using the MB-loaded polyacrylamide nanoparticles was conducted on rat C6 glioma tumor cells with positive photodynamic results. The encapsulation of MB in nanoparticles should diminish the interaction of this PS with the biological milieu, thus facilitating its systemic administration. Furthermore, the concept of the drug-delivering nanoparticles has been extended to a new type of dynamic nanoplatform (DNP) that only delivers 1 O 2 . This DNP could also be used as a targeted multifunctional platform for combined diagnostics and therapy of cancer.en_US
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dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights2005 American Society for Photobiologyen_US
dc.titlePhotodynamic Characterization and In Vitro Application of Methylene Blue-containing Nanoparticle Platforms ¶en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid15595888en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74716/1/j.1751-1097.2005.tb00181.x.pdf
dc.identifier.doi10.1111/j.1751-1097.2005.tb00181.xen_US
dc.identifier.sourcePhotochemistry and Photobiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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