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A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers

dc.contributor.authorNeedleman, Ianen_US
dc.contributor.authorSuvan, Jeanen_US
dc.contributor.authorGilthorpe, Mark S.en_US
dc.contributor.authorTucker, Richarden_US
dc.contributor.authorSt George, Geoffen_US
dc.contributor.authorGiannobile, William V.en_US
dc.contributor.authorTonetti, Maurizioen_US
dc.contributor.authorJarvis, Martinen_US
dc.date.accessioned2010-06-01T21:44:55Z
dc.date.available2010-06-01T21:44:55Z
dc.date.issued2007-04en_US
dc.identifier.citationNeedleman, Ian; Suvan, Jean; Gilthorpe, Mark S.; Tucker, Richard; St George, Geoff; Giannobile, William; Tonetti, Maurizio; Jarvis, Martin (2007). "A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers." Journal of Clinical Periodontology 34(4): 325-333. <http://hdl.handle.net/2027.42/74791>en_US
dc.identifier.issn0303-6979en_US
dc.identifier.issn1600-051Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74791
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17324155&dopt=citationen_US
dc.description.abstractBackground/Aim : Tobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy. Material and Methods : This was a parallel arm, randomized, identical placebo-controlled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling. Results : Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level −0.19 mm/month (95% CI=−0.34, 0.04; p =0.012) and probing depth 0.30 mm/month (95% CI=−0.42, −0.17; p <0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months. Conclusions : This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers.en_US
dc.format.extent142433 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2007 Blackwell Munksgaarden_US
dc.subject.otherDental Scalingen_US
dc.subject.otherPeriodontal Diseasesen_US
dc.subject.otherRandomized-controlled Trialen_US
dc.subject.otherSmokingen_US
dc.subject.otherTetracyclineen_US
dc.titleA randomized-controlled trial of low-dose doxycycline for periodontitis in smokersen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine and Michigan Centre for Oral Health research, University of Michigan, Ann Arbor, MI, USA ;en_US
dc.contributor.affiliationotherDepartment of Periodontology and International Centre for Evidence-Based Oral Health, UCL Eastman Dental Institute, London, UK ;en_US
dc.contributor.affiliationotherBiostatistics Unit, Centre for Epidemiology & Biostatistics, University of Leeds, Leeds, UK ;en_US
dc.contributor.affiliationotherDivision of Periodontology, Dept of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Centre, Farmington, CI, USA ;en_US
dc.contributor.affiliationotherHealth Behaviour Unit, Department of Epidemiology, UCL, London, UKen_US
dc.identifier.pmid17324155en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74791/1/j.1600-051X.2007.01058.x.pdf
dc.identifier.doi10.1111/j.1600-051X.2007.01058.xen_US
dc.identifier.sourceJournal of Clinical Periodontologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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