Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis
dc.contributor.author | Palys, Michael D. | en_US |
dc.contributor.author | Haffajee, Anne D. | en_US |
dc.contributor.author | Socransky, Sigmund S. | en_US |
dc.contributor.author | Giannobile, William V. | en_US |
dc.date.accessioned | 2010-06-01T21:46:03Z | |
dc.date.available | 2010-06-01T21:46:03Z | |
dc.date.issued | 1998-11 | en_US |
dc.identifier.citation | Palys, Michael D.; Haffajee, Anne D.; Socransky, Sigmund S.; Giannobile, William V. (1998). "Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis." Journal of Clinical Periodontology 25(11): 865-871. <http://hdl.handle.net/2027.42/74809> | en_US |
dc.identifier.issn | 0303-6979 | en_US |
dc.identifier.issn | 1600-051X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74809 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9846794&dopt=citation | en_US |
dc.description.abstract | Crevicular fluid pyridinoline cross-linked carboxyterminal telopeptide of type 1 collagen (ICTP) is predictive for future alveolar bone loss in experimental periodontitis in dogs. The present study sought to relate ICTP to a panel of subgingival species in subjects exhibiting various clinical presentations such as health ( n = 7), gingivitis ( n = 8) and periodontitis (n=21), 28 subgingival plaque and GCF samples were taken from mesiobuccal sites m each of 36 subjects. The presence and levels of 40 subgtngivai taxa were determined in plaque samples using whole genomic DNA probes and checkerboard DNA-DNA hybridization. GCF ICTP levels were quantified using radioimmunoassay (RIA). Clinical assessments made at the same sites included: BOP, gingival redness, plaque, pocket depth, and attachment level. Differences among ICTP levels in the 3 subject groups were sought using the Kruskal-Wallis test. Relationships between ICTP levels and clinical parameters as well as subgingival species were determined by regression analysis. The results demonstrated significant differences among disease categories for GCF ICTP levels for healthy (1.1+0.6 pg/site (mean±SEM)) gingivitis (14.8±6.6 pg/site) and penodontitts subjects (30.3 + 5.7 pg/site) ( p = 0.0017). ICTP levels related modestly to several clinical parameters. Regression analysis indicated that ICTP levels correlated strongly with mean subject levels of several periodontal pathogens including B. forsythus, P. gingivitis, P. intermedia, P. nigrescens and T. dentcola ( p < 0.01). The data indicate that there is a positive relationship between the putative bone resorptive marker ICTP and periodontal pathogens. | en_US |
dc.format.extent | 5549433 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1998 Munksgaard | en_US |
dc.subject.other | Periodontitis | en_US |
dc.subject.other | Gingival Crevicular Fluid | en_US |
dc.subject.other | Periodontal Pathogens | en_US |
dc.subject.other | Bone Resorption | en_US |
dc.subject.other | Pyridinoline Cross-links | en_US |
dc.subject.other | Human Studies | en_US |
dc.title | Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan School of Dentistry, Ann Arbor, Michigan USA | en_US |
dc.contributor.affiliationother | Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts USA | en_US |
dc.contributor.affiliationother | Department of Periodontology, Forsyth Dental Center, Boston, Massachusetts USA | en_US |
dc.identifier.pmid | 9846794 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74809/1/j.1600-051X.1998.tb02383.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-051X.1998.tb02383.x | en_US |
dc.identifier.source | Journal of Clinical Periodontology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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