Helicobacter pylori test-and-treat intervention compared to usual care in primary care patients with suspected peptic ulcer disease in the United States
dc.contributor.author | Ladabaum, Uri | en_US |
dc.contributor.author | Fendrick, A. Mark | en_US |
dc.contributor.author | Glidden, David | en_US |
dc.contributor.author | Scheiman, James M. | en_US |
dc.date.accessioned | 2010-06-01T21:47:22Z | |
dc.date.available | 2010-06-01T21:47:22Z | |
dc.date.issued | 2002-12 | en_US |
dc.identifier.citation | Ladabaum, Uri; Fendrick, A. Mark; Glidden, David; Scheiman, James M . (2002). " Helicobacter pylori test-and-treat intervention compared to usual care in primary care patients with suspected peptic ulcer disease in the United States." The American Journal of Gastroenterology 97(12): 3007-3014. <http://hdl.handle.net/2027.42/74830> | en_US |
dc.identifier.issn | 0002-9270 | en_US |
dc.identifier.issn | 1572-0241 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74830 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12492183&dopt=citation | en_US |
dc.description.abstract | The Helicobacter pylori ( H. pylori ) “test-and-treat” strategy in uninvestigated dyspepsia is an effective alternative to prompt endoscopy. Our aims were to determine whether the combination of an educational session and availability of office-based H. pylori testing (test-and-treat intervention [TTI]) increases use of the test-and-treat strategy by primary care practitioners and whether it improves patient outcomes. Methods : We conducted a 1-yr prospective trial of patients with suspected peptic ulcer disease in six primary care centers, three with TTI and three designated as usual care controls (UCC). Results : H. pylori testing was performed in 81% of 54 TTI patients and in 49% of 39 UCC patients ( p = 0.004). TTI and UCC patients had similar gastroenterology referral rates (24% vs 33%, p = 0.33), endoscopy or upper GI radiography rates (30% vs 31%, p = 0.91), and primary care visits per patient (3.1 ± 2.8 vs 3.1 ± 2.6, p = 0.92). TTI patients were less likely than UCC patients to receive repeated antisecretory medication prescriptions (35% vs 66%, p = 0.003). Symptomatic status at 1 yr and satisfaction with medical care did not differ between groups. Median (and interquartile range) annualized disease-related expenditures per patient were $454 ($162–932) for TTI and $576 ($327–1435) for UCC patients ( p = 0.17). Conclusions : The combination of an educational session and availability of office-based H. pylori testing may increase acceptance of the test-and-treat strategy by primary care providers. It remains to be determined whether increased use of the test-and-treat strategy yields significant improvements in clinical and economic outcomes compared to usual care. | en_US |
dc.format.extent | 77341 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2002 by Am. Coll. of Gastroenterology | en_US |
dc.title | Helicobacter pylori test-and-treat intervention compared to usual care in primary care patients with suspected peptic ulcer disease in the United States | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Health Management and Policy, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Consortium for Health Outcomes, Innovation, and Cost-Effectiveness Studies (CHOICES), University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA | en_US |
dc.identifier.pmid | 12492183 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74830/1/j.1572-0241.2002.07118.x.pdf | |
dc.identifier.doi | 10.1111/j.1572-0241.2002.07118.x | en_US |
dc.identifier.source | The American Journal of Gastroenterology | en_US |
dc.identifier.citedreference | Talley N.J., Silverstein M.D., Agreus L., et al. AGA technical review: Evaluation of dyspepsia. Gastroenterology 1998; 114: 582 – 595. | en_US |
dc.identifier.citedreference | Axon A.T., Bell G.D., Jones R.H., et al. Guidelines on appropriate indications for upper gastrointestinal endoscopy. Working Party of the Joint Committee of the Royal College of Physicians of London, Royal College of Surgeons of England, Royal College of Anaesthetists, Association of Surgeons, the British Society of Gastroenterology, and the Thoracic Society of Great Britain. Br Med J 1995; 310: 853 – 856. | en_US |
dc.identifier.citedreference | 3. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter Pylori Study Group. Gut 1997; 41: 8 – 13. | en_US |
dc.identifier.citedreference | 4. American Gastroenterological Association medical position statement: Evaluation of dyspepsia. Gastroenterology 1998; 114: 579 – 581. | en_US |
dc.identifier.citedreference | Lam S.K., Talley N.J. Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection. J Gastroenterol Hepatol 1998; 13: 1 – 12. | en_US |
dc.identifier.citedreference | Veldhuyzen van Zanten S.J., Flook N., Chiba N., et al. An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori. Canadian Dyspepsia Working Group. Can Med Assoc J 2000; 162 ( suppl 12 ): S3 – S23. | en_US |
dc.identifier.citedreference | Peterson W.L., Fendrick A.M., Cave D.R., et al. Helicobacter pylori-related disease: Guidelines for testing and treatment. Arch Intern Med 2000; 160: 1285 – 1291. | en_US |
dc.identifier.citedreference | Sobala G.M., Crabtree J.E., Pentith J.A., et al. Screening dyspepsia by serology to Helicobacter pylori. Lancet 1991; 338: 94 – 96. | en_US |
dc.identifier.citedreference | Patel P., Khulusi S., Mendall M.A., et al. Prospective screening of dyspeptic patients by Helicobacter pylori serology. Lancet 1995; 346: 1315 – 1318. | en_US |
dc.identifier.citedreference | Fendrick A.M., Chernew M.E., Hirth R.A., et al. Alternative management strategies for patients with suspected peptic ulcer disease. Ann Intern Med 1995; 123: 260 – 268. | en_US |
dc.identifier.citedreference | Silverstein M.D., Petterson T., Talley N.J. Initial endoscopy or empirical therapy with or without testing for Helicobacter pylori for dyspepsia: A decision analysis. Gastroenterology 1996; 110: 72 – 83. | en_US |
dc.identifier.citedreference | Lassen A.T., Pedersen F.M., Bytzer P., et al. Helicobacter pylori test-and-eradicate versus prompt endoscopy for management of dyspeptic patients: A randomised trial. Lancet 2000; 356: 455 – 460. | en_US |
dc.identifier.citedreference | Jones R., Tait C., Sladen G., et al. A trial of a test-and-treat strategy for Helicobacter pylori positive dyspeptic patients in general practice. Int J Clin Pract 1999; 53: 413 – 416. | en_US |
dc.identifier.citedreference | Weingarten S. Translating practice guidelines into patient care: Guidelines at the bedside. Chest 2000; 118: 4S – 7S. | en_US |
dc.identifier.citedreference | Bero L.A., Grilli R., Grimshaw J.M., et al. Closing the gap between research and practice: An overview of systematic reviews of interventions to promote the implementation of research findings. The Cochrane Effective Practice and Organization of Care Review Group. Br Med J 1998; 317: 465 – 468. | en_US |
dc.identifier.citedreference | Ladabaum U., Fendrick A.M., Scheiman J.M. Outcomes of initial noninvasive Helicobacter pylori testing in U.S. primary care patients with uninvestigated dyspepsia. Am J Gastroenterol 2001; 96: 2051 – 2057. | en_US |
dc.identifier.citedreference | Chey W.D., Murthy U., Shaw S., et al. A comparison of three fingerstick, whole blood antibody tests for Helicobacter pylori infection: A United States, multicenter trial. Am J Gastroenterol 1999; 94: 1512 – 1516. | en_US |
dc.identifier.citedreference | Ladas S.D., Malamou H., Giota G., et al. Prospective evaluation of a whole-blood antibody test (FlexPack HP) for in-office diagnosis of Helicobacter pylori infection in untreated patients. Eur J Gastroenterol Hepatol 2000; 12: 727 – 731. | en_US |
dc.identifier.citedreference | Agresti A., An introduction to categorical data analysis. New York: Wiley, 1996. | en_US |
dc.identifier.citedreference | Liang K.Y., Zeger S.L. Longitudinal data analysis using generalized linear models. Biometrika 1986; 73: 13 – 22. | en_US |
dc.identifier.citedreference | Fennerty M.B., Lieberman D.A., Vakil N., et al. Effectiveness of Helicobacter pylori therapies in a clinical practice setting. Arch Intern Med 1999; 159: 1562 – 1566. | en_US |
dc.identifier.citedreference | Fendrick A.M., Chey W.D., Margaret N., et al. Symptom status and the desire for Helicobacter pylori confirmatory testing after eradication therapy in patients with peptic ulcer disease. Am J Med 1999; 107: 133 – 136. | en_US |
dc.identifier.citedreference | Chey W.D., Fendrick A.M. Noninvasive Helicobacter pylori testing for the “test-and-treat” strategy: A decision analysis to assess the effect of past infection on test choice. Arch Intern Med 2001; 161: 2129 – 2132. | en_US |
dc.identifier.citedreference | Asante M.A., Mendall M., Patel P., et al. A randomized trial of endoscopy vs no endoscopy in the management of seronegative Helicobacter pylori dyspepsia. Eur J Gastroenterol Hepatol 1998; 10: 983 – 989. | en_US |
dc.identifier.citedreference | Heaney A., Collins J.S., Tham T.C., et al. A prospective study of the management of the young Helicobacter pylori negative dyspeptic patient—can gastroscopies be saved in clinical practice?. Eur J Gastroenterol Hepatol 1998; 10: 953 – 956. | en_US |
dc.identifier.citedreference | Heaney A., Collins J.S., Watson R.G., et al. A prospective randomised trial of a “test and treat” policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic. Gut 1999; 45: 186 – 190. | en_US |
dc.identifier.citedreference | Duggan A., Elliot C., Tolley K., et al. Randomized controlled trial of four dyspepsia management strategies in primary care with 12 months follow-up. Gastroenterology 2000; 118: A438 (abstract). | en_US |
dc.identifier.citedreference | Ofman J.J., Rabeneck L. The effectiveness of endoscopy in the management of dyspepsia: A qualitative systematic review. Am J Med 1999; 106: 335 – 346. | en_US |
dc.identifier.citedreference | Laheij R.J., Severens J.L., Van de Lisdonk E.H., et al. Randomized controlled trial of omeprazole or endoscopy in patients with persistent dyspepsia: A cost-effectiveness analysis. Aliment Pharmacol Ther 1998; 12: 1249 – 1256. | en_US |
dc.identifier.citedreference | Wiklund I., Glise H., Jerndal P., et al. Does endoscopy have a positive impact on quality of life in dyspepsia?. Gastrointest Endosc 1998; 47: 449 – 454. | en_US |
dc.identifier.citedreference | Hirth R.A., Bloom B.S., Chernew M.E., et al. Willingness to pay for diagnostic certainty: Comparing patients, physicians, and managed care executives. J Gen Intern Med 1999; 14: 193 – 195. | en_US |
dc.identifier.citedreference | Hession P.T., Malagelada J. The initial management of uninvestigated dyspepsia in younger patients-the value of symptom-guided strategies should be reconsidered. Aliment Pharmacol Ther 2000; 14: 379 – 388 ( review article ). | en_US |
dc.identifier.citedreference | Nomura A., Stemmermann G.N., Chyou P.H., et al. Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann Intern Med 1994; 120: 977 – 981. | en_US |
dc.identifier.citedreference | Hsu P.I., Lai K.H., Tseng H.H., et al. Eradication of Helicobacter pylori prevents ulcer development in patients with ulcer-like functional dyspepsia. Aliment Pharmacol Ther 2001; 15: 195 – 201. | en_US |
dc.identifier.citedreference | Scheiman J.M., Bandekar R.R., Chernew M.E., et al. Helicobacter pylori screening for individuals requiring chronic NSAID therapy: A decision analysis. Aliment Pharmacol Ther 2001; 15: 63 – 71. | en_US |
dc.identifier.citedreference | Chan F.K., Chung S.C., Suen B.Y., et al. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 2001; 344: 967 – 973. | en_US |
dc.identifier.citedreference | Parsonnet J., Harris R.A., Hack H.M., et al. Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: A mandate for clinical trials. Lancet 1996; 348: 150 – 154. | en_US |
dc.identifier.citedreference | Fendrick A.M., Chernew M.E., Hirth R.A., et al. Clinical and economic effects of population-based Helicobacter pylori screening to prevent gastric cancer. Arch Intern Med 1999; 159: 142 – 148. | en_US |
dc.identifier.citedreference | Uemura N., Okamoto S., Yamamoto S., et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784 – 789. | en_US |
dc.identifier.citedreference | Moayyedi P., Soo S., Deeks J., et al. Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia Review Group. Br Med J 2000; 321: 659 – 664. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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