Transfusion Management of Patients with IgA Deficiency and Anti-IgA during Liver Transplantation
dc.contributor.author | Davenport, Robertson D. | en_US |
dc.contributor.author | Burnie, K. L. | en_US |
dc.contributor.author | Barr, R. M. | en_US |
dc.date.accessioned | 2010-06-01T21:49:00Z | |
dc.date.available | 2010-06-01T21:49:00Z | |
dc.date.issued | 1992-11 | en_US |
dc.identifier.citation | Davenport, R.D.; Burnie, K.L.; Barr, R.M. (1992). "Transfusion Management of Patients with IgA Deficiency and Anti-IgA during Liver Transplantation." Vox Sanguinis 63(4): 247-250. <http://hdl.handle.net/2027.42/74856> | en_US |
dc.identifier.issn | 0042-9007 | en_US |
dc.identifier.issn | 1423-0410 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74856 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1481472&dopt=citation | en_US |
dc.description.abstract | Severe anaphylactic or allergic reactions may occur during blood transfusion to patients who are IgA-deficient and have anti-IgA in their blood, particularly those with class-specific antibodies. These patients are a particular challenge to the hospital transfusion service when large volumes of blood components are required for transfusion support, as in liver transplantation. We have successfully provided blood components for 3 such patients undergoing liver transplantation. Red cells were washed manually or by automated technique. Platelets were washed manually. All plasma was from IgA-deficient donors. One patient's entire plasma requirements were supplied by autologous plasmapheresis. Serial determinations of IgA levels and anti-IgA titers in 1 patient demonstrated an abrupt fall in anti-IgA with the appearance of barely detectable amounts of IgA during the surgery. IgA-containing plasma cells were demonstrated in the biopsies of liver homografts of 2 patients following transplantation. IgA deficiency with anti-IgA can be successfully managed during liver transplantation with advance planning. | en_US |
dc.format.extent | 282754 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1992 Blackwell Publishing Ltd | en_US |
dc.title | Transfusion Management of Patients with IgA Deficiency and Anti-IgA during Liver Transplantation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Hospitals, Ann Arbor, Mich., USA; University Hospital, London, Ontario, Canada | en_US |
dc.identifier.pmid | 1481472 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74856/1/j.1423-0410.1992.tb01229.x.pdf | |
dc.identifier.doi | 10.1111/j.1423-0410.1992.tb01229.x | en_US |
dc.identifier.source | Vox Sanguinis | en_US |
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dc.identifier.citedreference | Koistinen J., Fedenberg HH: Antibodies to allotypes, with special reference to the allotypes of immunglobulin A; in Rose NR, Friedman H. ( eds ): Manual of Clinical Immunology. Washington, American Society for Microbiology, 1976. | en_US |
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dc.identifier.citedreference | Sloand EM, Fox SM, Banks SM, Klein HG: Preparation of IgA-deficient platelets. Transfusion 1990; 30: 322 – 326. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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