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Chemokine responses in schistosomal antigen-elicited granuloma formation *
dc.contributor.authorChiu, Bo-Chinen_US
dc.contributor.authorChensue, Stephen W.en_US
dc.date.accessioned2010-06-01T21:49:08Z
dc.date.available2010-06-01T21:49:08Z
dc.date.issued2002-06en_US
dc.identifier.citationChiu, Bo-Chin; Chensue, Stephen W. (2002). "Chemokine responses in schistosomal antigen-elicited granuloma formation * ." Parasite Immunology 24(6): 285-294. <http://hdl.handle.net/2027.42/74858>en_US
dc.identifier.issn0141-9838en_US
dc.identifier.issn1365-3024en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74858
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12102713&dopt=citationen_US
dc.description.abstractHost immune systems have evolved specialized responses to multicellular parasites. This is well represented by the type 2 granulomatous response to Schistosoma mansoni egg antigens, which is an eosinophil-rich inflammatory response mediated by Th2-associated cytokines. Using Ag-bead models of pulmonary granuloma formation in mice, we defined characteristic chemokine (CK) profiles in the granulomatous lungs. Our findings point to a role for C-C chemokine receptor-2 (CCR2) and CCR3 agonists such as monocyte chemotactic proteins (MCPs) 1/CCL2, 3/CCL7 and 5/CCL12 as important participants that are subject to regulation by Th2 cytokines interleukin (IL)-4 and IL-13. CCR4 and CCR8 agonists are also likely contributors. Analysis of CK receptor knockout mice revealed that CCR2 ligands (e.g. MCP-1 and 5) promoted early phase granuloma macrophage accumulation, whereas anti-MCP-3 (CCL7) antibody treatment abrogated eosinophil recruitment. CCR8 knockout mice also demonstrated impaired eosinophil recruitment but this appeared to be related to impaired Th2 cell function. Transcript analysis of CD4 + T cells generated during schistosome granuloma formation failed to show biased CCR8 expression but, having a more limited receptor repertoire, these cells were likely more dependent on CCR8 ligands. Together, these studies indicate an intricate involvement of chemokines in various stages and aspects of schistosomal egg Ag-elicited granuloma formation.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rightsBlackwell Science, 2002en_US
dc.subject.otherChemokinesen_US
dc.subject.otherTh1en_US
dc.subject.otherTh2en_US
dc.subject.otherChemokine Receptorsen_US
dc.subject.otherGranulomasen_US
dc.titleChemokine responses in schistosomal antigen-elicited granuloma formation *en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI anden_US
dc.contributor.affiliationotherDepartment of Pathology and Laboratory Medicine, Veterans Affairs Healthcare System, Ann Arbor, MI, USAen_US
dc.identifier.pmid12102713en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74858/1/j.1365-3024.2002.00466.x.pdf
dc.identifier.doi10.1046/j.1365-3024.2002.00466.xen_US
dc.identifier.sourceParasite Immunologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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