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Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress

dc.contributor.authorSowers, MaryFran R.en_US
dc.contributor.authorMcConnell, Daniel S.en_US
dc.contributor.authorJannausch, Mary L.en_US
dc.contributor.authorRandolph, John F. Jr.en_US
dc.contributor.authorBrook, Robert D.en_US
dc.contributor.authorGold, Ellen B.en_US
dc.contributor.authorCrawford, Sybil Len_US
dc.contributor.authorLasley, Billen_US
dc.date.accessioned2010-06-01T21:54:31Z
dc.date.available2010-06-01T21:54:31Z
dc.date.issued2008-05en_US
dc.identifier.citationSowers, MaryFran; McConnell, Daniel; Jannausch, Mary L.; Randolph, John F.; Brook, Robert; Gold, Ellen B.; Crawford, Sybil; Lasley, Bill (2008). "Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress." Clinical Endocrinology 68(5): 806-813. <http://hdl.handle.net/2027.42/74943>en_US
dc.identifier.issn0300-0664en_US
dc.identifier.issn1365-2265en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74943
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17980014&dopt=citationen_US
dc.description.abstractObjective  Oestradiol (E2) and its metabolites 2-hydroxyoestrone (2-OHE1) and 16Α-hydroxyoestrone (16Α-OHE1) are thought to curtail the greater oxidative stress found in the development and progression of disease conditions including atherosclerosis. We related oestrogen levels to F 2a -isoprostane levels, a biomarker of oxidative stress. Design and participants  Data were obtained from 1647 women, aged 47–57 years, participating in the fifth annual follow-up of the Study of Women's Health Across the Nation (SWAN), a study of the menopausal transition. Measurements  Serum E2 and urinary 2-OHE1 and 16Α-OHE1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) and urinary F 2a -isoprostanes were measured by enzyme immunoassay (EIA). Results  F 2a -isoprostane concentrations were elevated in women who smoked, a behaviour associated with increased oxidative stress, but not in stages of the natural menopause. Mean F 2a -isoprostane concentrations among pre- and postmenopausal women who smoked were 1082 and 1064 pg/ml, respectively, values double those in pre- (343 pg/ml) and postmenopausal (379 pg/ml) nonsmoking women. 2-OHE1 and F 2a -isoprostane concentrations were positively and highly correlated (partial correlations Ρ Y|X  = 0·44 and Ρ Y|X  = 0·43 in pre- and postmenopausal women, respectively). Similarly, 16Α-OHE1 concentrations were positively and highly correlated with F 2a -isoprostane concentrations (Ρ Y|X  = 0·52 and Ρ Y|X  = 0·59 in pre- and postmenopausal women, respectively). E2 was significantly correlated with F 2a -isoprostanes only in postmenopausal women (Ρ Y|X  = 0·20). Associations were adjusted for age, body mass index (BMI), race/ethnicity, lipids, physical activity level and alcohol consumption. Conclusions  This study does not support the commonly held hypothesis that levels of endogenous E2 or its oestrone metabolites favourably modify oxidative stress by decreasing F2 a -isoprostane levels.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsJournal compilation © 2007 Blackwell Publishing Ltden_US
dc.titleOestrogen metabolites in relation to isoprostanes as a measure of oxidative stressen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI,en_US
dc.contributor.affiliationum† Department of Obstetrics and Gynecology, University of Michigan Health Sciences System, Ann Arbor, MI,en_US
dc.contributor.affiliationum† Department of Cardiovascular Medicine, University of Michigan Health Sciences System, Ann Arbor, MI,en_US
dc.contributor.affiliationother§ Division of Epidemiology, Department of Public Health Sciences, University of California School of Medicine, Davis, CA,en_US
dc.contributor.affiliationother¶ Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA anden_US
dc.contributor.affiliationother** Department of Population Health and Reproduction, University of California, Davis, CA, USAen_US
dc.identifier.pmid17980014en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74943/1/j.1365-2265.2007.03108.x.pdf
dc.identifier.doi10.1111/j.1365-2265.2007.03108.xen_US
dc.identifier.sourceClinical Endocrinologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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