ADH Levels during Salt Depletion in Dogs *
dc.contributor.author | Brennan, Leonard A. | en_US |
dc.contributor.author | Bonjour, Jean-Philippe | en_US |
dc.contributor.author | Malvin, Richard L. | en_US |
dc.date.accessioned | 2010-06-01T22:00:18Z | |
dc.date.available | 2010-06-01T22:00:18Z | |
dc.date.issued | 1971-02 | en_US |
dc.identifier.citation | Brennan, Leonard A.; Bonjour, Jean-Philippe; Malvin, Richard L. (1971). "ADH Levels during Salt Depletion in Dogs * ." European Journal of Clinical Investigation 2(1): 43-46. <http://hdl.handle.net/2027.42/75034> | en_US |
dc.identifier.issn | 0014-2972 | en_US |
dc.identifier.issn | 1365-2362 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75034 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4333502&dopt=citation | en_US |
dc.description.abstract | Two groups of trained dogs were subjected to sodium chloride depletion and plasma ADH concentration, renin activity, plasma sodium, plasma osmolality, blood volume, hematocrit and body weight were measured. In one group of animals, sodium depletion was created by restricting intake to 5 mEq/24 h. Despite a statistically significant decrease in body weight and blood volume and a corresponding increase in plasma renin activity, plasma ADH concentration was not seen to change significantly from control values. Similar findings were seen in a second group of dogs which were given a diuretic in addition to dietary sodium restriction. In these animals the decrease in blood volume and rise in plasma renin activity were proportionately greater. Plasma ADH concentration was not observed to change significantly in this group of animals either. Both groups of animals developed significant hyponatremia during the experiment. It is concluded that in these dogs, the secretion of ADH was not suppressed and consequently hyponatremia developed. It is suggested that endogenous angiotensin was responsible for the continued secretion of ADH at control levels. | en_US |
dc.format.extent | 342002 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1971 European Society for Clinical Investigation | en_US |
dc.subject.other | ADH | en_US |
dc.subject.other | Renin-angiotensin | en_US |
dc.subject.other | Hyponatremia | en_US |
dc.subject.other | Salt Depletion | en_US |
dc.subject.other | Blood Volume | en_US |
dc.subject.other | Diuretic | en_US |
dc.title | ADH Levels during Salt Depletion in Dogs * | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, Michigan U.S.A. | en_US |
dc.identifier.pmid | 4333502 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75034/1/j.1365-2362.1971.tb00567.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2362.1971.tb00567.x | en_US |
dc.identifier.source | European Journal of Clinical Investigation | en_US |
dc.identifier.citedreference | Bonjour, J.-P., Malvin, R. L.: Plasma concentrations of ADH in conscious and anesthetized dogs. Amer. J. Physiol. 218, 1128 ( 1970 ). | en_US |
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dc.identifier.citedreference | McCance, R. A.: Experimental human salt deficiency. Lancet 1936 II, 823. | en_US |
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dc.identifier.citedreference | Gauer, O. H.: Osmocontrol versus volume control. Fed. Proc. 27, 1132 ( 1968 ). | en_US |
dc.identifier.citedreference | Johnson, J. A., Zehr, J. E., Moore, W. W.: Effects of separate and concurrent osmotic and volume stimuli on plasma ADH in sheep. Amer. J. Physiol. 218, 1273 ( 1970 ). | en_US |
dc.identifier.citedreference | Bonjour, J.-P., Malvin, R. L.: Stimulation of ADH release by the renin-angiotensin system. Amer. J. Physiol. 218, 1555 ( 1970 ). | en_US |
dc.identifier.citedreference | Mouw, D., Bonjour, J.-P., Malvin, R. L., Vander, A. J.: Central action of angiotensin in stimulating ADH release. Amer. J. Physiol. 220, 239 ( 1971 ). | en_US |
dc.identifier.citedreference | Henry, J. P., Gupta, P. D., Meehan, J. P., Sinclair, R., Share, L.: The role of afferenta from the low-pressure system in the release of antidiuretic hormone during non-hypotensive hemorrhage. Canad. J. Physiol. Pharmacol. 46, 287 ( 1967 ). | en_US |
dc.identifier.citedreference | Bull, M. B., Hillman, R. S., Cannon, P. J., Laragh, J. H.: Renin and aldosterone secretion in man as influenced by changes in electrolyte balance and blood volume. Circulat. Res. 27, 953 ( 1970 ). | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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