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Inhibition of B-cell death does not restore T-cell-dependent immune responses in CD40-deficient mice
dc.contributor.authorMerino, Jesúsen_US
dc.contributor.authorDíez, Miguel A.en_US
dc.contributor.authorMuñiz, Maríaen_US
dc.contributor.authorBuelta, Luisen_US
dc.contributor.authorNúñez, Gabrielen_US
dc.contributor.authorLópez-Hoyos, Marcosen_US
dc.contributor.authorMerino, Ramónen_US
dc.date.accessioned2010-06-01T22:01:24Z
dc.date.available2010-06-01T22:01:24Z
dc.date.issued2003-08en_US
dc.identifier.citationMerino, JesÚs; DÍez, Miguel A.; MuÑiz, MarÍa; Buelta, Luis; NÚÑez, Gabriel; LÓpez-Hoyos, Marcos; Merino, RamÓn (2003). "Inhibition of B-cell death does not restore T-cell-dependent immune responses in CD40-deficient mice." Immunology 109(4): 504-509. <http://hdl.handle.net/2027.42/75051>en_US
dc.identifier.issn0019-2805en_US
dc.identifier.issn1365-2567en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75051
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12871216&dopt=citationen_US
dc.description.abstractSignalling through CD40 is essential for the development of immunoglobulin G (IgG) antibody responses, germinal centres and B-cell memory against T-dependent antigens. In addition, engagement of CD40 in B cells promotes cell survival by inducing the expression of anti-apoptotic members of the bcl-2 family of cell-death regulators. In the present study we analysed whether T-dependent immune responses can be developed in mice deficient in CD40 if the anti-apoptotic activity mediated by the engagement of CD40 in B cells is compensated by the constitutive over-expression of anti-apoptotic genes of the bcl-2 family. We showed that the over-expression of either hbcl-2 or hbcl-x L transgenes in B cells is not sufficient to restore IgG antibody responses and germinal centre formation in CD40-deficient mice. These results indicate that CD40 functions, other than those mediated through survival, are required for the establishment of T-dependent B-cell responses.en_US
dc.format.extent228652 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Science, Ltden_US
dc.rights© 2003 Blackwell Publishing Ltden_US
dc.titleInhibition of B-cell death does not restore T-cell-dependent immune responses in CD40-deficient miceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum† Department of Pathology, University of Michigan, Ann Arbor, MI, USA,en_US
dc.contributor.affiliationother* Laboratory of Immunology, Department of Molecular Biology, (Unit associated with CIB/CSIC), University of Cantabria, Santander, Spain,en_US
dc.contributor.affiliationother† Department of Medical and Surgery Sciences, University of Cantabria, Santander, Spain,en_US
dc.contributor.affiliationother§ Immunology anden_US
dc.contributor.affiliationother¶ Research Unit, Hospital Universitario MarquÉs de Valdecilla, Santander, Spainen_US
dc.identifier.pmid12871216en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75051/1/j.1365-2567.2003.01690.x.pdf
dc.identifier.doi10.1046/j.1365-2567.2003.01690.xen_US
dc.identifier.sourceImmunologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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