Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors
dc.contributor.author | Jin, Yafei | en_US |
dc.contributor.author | Zhong, H. | en_US |
dc.contributor.author | Omnaas, John R. | en_US |
dc.contributor.author | Neubig, Richard R. | en_US |
dc.contributor.author | Mosberg, Henry I. | en_US |
dc.date.accessioned | 2010-06-01T22:06:03Z | |
dc.date.available | 2010-06-01T22:06:03Z | |
dc.date.issued | 2004-02 | en_US |
dc.identifier.citation | Jin, Y . ; Zhong, H . ; Omnaas, J.R . ; Neubig, R.R . ; Mosberg, H.I . (2004). "Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors." The Journal of Peptide Research 63(2): 141-146. <http://hdl.handle.net/2027.42/75124> | en_US |
dc.identifier.issn | 1397-002X | en_US |
dc.identifier.issn | 1399-3011 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75124 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15009535&dopt=citation | en_US |
dc.format.extent | 208036 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2004 Blackwell Munksgaard | en_US |
dc.subject.other | Cyclic Peptides | en_US |
dc.subject.other | G-proteins | en_US |
dc.subject.other | GTPase-activating Proteins | en_US |
dc.subject.other | Protein–Protein Interactions | en_US |
dc.subject.other | Regulator of G-protein Signaling | en_US |
dc.title | Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 15009535 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75124/1/j.1399-3011.2003.00114.x.pdf | |
dc.identifier.doi | 10.1111/j.1399-3011.2003.00114.x | en_US |
dc.identifier.source | The Journal of Peptide Research | en_US |
dc.identifier.citedreference | Druey, K.M., Blumer, K.J., Kang, V.H. & Kehrl, J.H. ( 1996 ) Inhibition of G-protein mediated MAP kinase activation by a new mammalian gene family. Nature 379, 742 – 746. | en_US |
dc.identifier.citedreference | Koelle, M.R. & Horvitz, H.R. ( 1996 ) EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84, 115 – 125. | en_US |
dc.identifier.citedreference | Siderovski, D.P., Strockbine, B. & Behe, C.I. ( 1999 ) Whither goest the RGS proteins ? Crit. Rev. Biochem. Mol. Biol. 34, 215 – 251. | en_US |
dc.identifier.citedreference | Hepler, J.R. ( 1999 ) Emerging roles for RGS proteins in cell signaling. Trends Pharmacol. Sci. 20, 376 – 382. | en_US |
dc.identifier.citedreference | De Vries, L., Zheng, B., Fischer, T., Elenko, E. & Farquhar, M.G. ( 2000 ) The regulator of G protein signaling family. Annu. Rev. Pharmacol. Toxicol. 40, 235 – 271. | en_US |
dc.identifier.citedreference | Zhong, H.L. & Neubig, R.R. ( 2001 ) RGS proteins: novel multifunctional drug targets. J. Pharmacol. Expl. Ther. 297, 837 – 845. | en_US |
dc.identifier.citedreference | Neubig, R.R. & Siderovski, D.P. ( 2002 ) Regulators of G-protein signaling as new central nervous system drug targets. Nat. Rev. Drug Discov. 1, 189 – 199. | en_US |
dc.identifier.citedreference | Tesmer, J.J.G., Berman, D.M., Gilman, A.F. & Sprang, S.R. ( 1997 ) Structure of RGS4 bound to AlF4-activated G(i alpha 1): stabilization of the transition state for GTP hydrolysis. Cell 89, 251 – 261. | en_US |
dc.identifier.citedreference | Lambright, D.G., Noel, J.P., Hamm, H.E. & Sigler, P.B. ( 1994 ) Structural determinants for activation of the alpha-subunit of a heterotrimeric G-protein. Nature 369, 621 – 628. | en_US |
dc.identifier.citedreference | Macdonald, R.L. & Olsen, R.W. ( 1994 ) GABA (A) receptor channels. Annu. Rev. Neurosci. 17, 569 – 602. | en_US |
dc.identifier.citedreference | Wade, S.M., Lim, W., Lan, K.L., Chung, D.A., Nanamori, M. & Neubig, R.R. ( 1999 ) Gi activator region of 2A-adrenergic receptors: distinct basic residues mediate Gi versus Gs activation. Mol. Pharmacol. 56, 1005 – 1013. | en_US |
dc.identifier.citedreference | Lan, K.L., Zhong, H.L., Nanamori, M. & Neubig, R.R. ( 2000 ) Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Gi and Go deactivation: G specificity of RGS4 and RGS7. J. Biol. Chem. 275, 33497 – 33503. | en_US |
dc.identifier.citedreference | Zhong, H., Wade, S.M., Woolf, P.J., Linderman, J.J., Traynor, J.R. & Neubig, R.R. ( 2003 ) A spatial focusing model for G protein signals: regulator of G protein signaling (RGS) protein-mediated kinetic scaffolding. J. Biol. Chem. 278, 7278 – 7284. | en_US |
dc.identifier.citedreference | Lan, K.-L., Sarvazyan, N.A., Taussig, R., Mackenzie, R.G., DiBello, P.R., Dohlman, H.G. & Neubig, R.R. ( 1998 ) A point mutation in Go and Gi1 blocks interaction with regulator of G protein signaling proteins. J. Biol. Chem. 273, 12794 – 12797. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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