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Ionic Mechanism of GABA A Biphasic Synaptic Potentials in Gustatory Nucleus of the Solitary Tract a
dc.contributor.authorGrabauskas, Gintautasen_US
dc.contributor.authorBradley, Robert M.en_US
dc.date.accessioned2010-06-01T22:10:51Z
dc.date.available2010-06-01T22:10:51Z
dc.date.issued1998-11en_US
dc.identifier.citationGrabauskas, Gintautas; Bradley, Robert M. (1998). "Ionic Mechanism of GABA A Biphasic Synaptic Potentials in Gustatory Nucleus of the Solitary Tract a ." Annals of the New York Academy of Sciences 855(1 OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM ): 486-487. <http://hdl.handle.net/2027.42/75200>en_US
dc.identifier.issn0077-8923en_US
dc.identifier.issn1749-6632en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75200
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9929643&dopt=citationen_US
dc.description.abstractGamma-aminobutyric acid (GABA) is the principal neurotransmitter of synaptic inhibition in the gustatory nucleus of the solitary tract (rNST). High-frequency activation of GABA neurons in the rNST results in biphasic inhibitory postsynaptic potentials (IPSPs) that are initially hyperpolarizing but then became depolarizing. Our results indicate that high-frequency stimulation evokes redistribution of Cl − and K + ions that shifts IPSP reversal potential in a more positive direction, which produces a biphasic or depolarizing IPSP.en_US
dc.format.extent139436 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsNew York Academy of Sciences 1998en_US
dc.titleIonic Mechanism of GABA A Biphasic Synaptic Potentials in Gustatory Nucleus of the Solitary Tract aen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelScience (General)en_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, USAen_US
dc.contributor.affiliationumDepartment of Physiology, Medical School, University of Michigan, Ann Arbor, Michigan 48109-0622, USAen_US
dc.identifier.pmid9929643en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75200/1/j.1749-6632.1998.tb10610.x.pdf
dc.identifier.doi10.1111/j.1749-6632.1998.tb10610.xen_US
dc.identifier.sourceAnnals of the New York Academy of Sciencesen_US
dc.identifier.citedreferenceBenninger, C., J. Kadis & D. A. Prince. 1980. Extracellular calcium and potassium changes in hippocampal slices. Brain Res. 187: 165 – 182.en_US
dc.identifier.citedreferenceGrabauskas, G. & R. M. Bradley. 1996. Synaptic interactions due to convergent input from gustatory afferent fibers in the rostral nucleus of the solitary tract. J. Neurophysiol. 76: 2919 – 2927.en_US
dc.identifier.citedreferenceKaila, K. 1994. Ionic basis of GABA A receptor channel function in the nervous system. Prog.Neurobiol. 42: 489 – 537.en_US
dc.identifier.citedreferenceStaley, K. J., B. L. Soldo & W. R. Proctor. 1995. Ionic mechanisms of neuronal excitation by inhibitory GABA A receptors. Science 269: 977 – 981.en_US
dc.identifier.citedreferenceWang, L. & R. M. Bradley. 1993. Influence of GABA on neurons of the gustatory zone of the rat nucleus of the solitary tract. Brain Res. 616: 144 – 153.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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