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The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoter

dc.contributor.authorKrukonis, Eric S.en_US
dc.contributor.authorYu, Rosa R.en_US
dc.contributor.authorDiRita, Victor J.en_US
dc.date.accessioned2010-06-01T22:13:13Z
dc.date.available2010-06-01T22:13:13Z
dc.date.issued2000-10en_US
dc.identifier.citationKrukonis, Eric S . ; Yu, Rosa R . ; DiRita, Victor J . (2000). "The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoter." Molecular Microbiology 38(1): 67-84. <http://hdl.handle.net/2027.42/75237>en_US
dc.identifier.issn0950-382Xen_US
dc.identifier.issn1365-2958en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75237
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11029691&dopt=citationen_US
dc.format.extent878845 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rightsBlackwell Science Ltden_US
dc.titleThe Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoteren_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0614, USA.en_US
dc.contributor.affiliationotherUnit for Laboratory Animal Medicine, anden_US
dc.identifier.pmid11029691en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75237/1/j.1365-2958.2000.02111.x.pdf
dc.identifier.doi10.1046/j.1365-2958.2000.02111.xen_US
dc.identifier.sourceMolecular Microbiologyen_US
dc.identifier.citedreferenceCarroll, P.A., Tashima, K.T., Rogers, M.B., DiRita, V.J., Calderwood, S.B. ( 1997 ) Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae. Mol Microbiol 25: 1099 – 1111.en_US
dc.identifier.citedreferenceChakrabarti, S.R., Chaudhuri, K., Sen, K., Das, J. ( 1996 ) Porins of Vibrio cholerae: purification and characterization of OmpU. J Bacteriol 178: 524 – 530.en_US
dc.identifier.citedreferenceChampion, G.A., Neely, M.N., Brennan, M.A., DiRita, V.J. ( 1997 ) A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains. Mol Microbiol 23: 323 – 331.en_US
dc.identifier.citedreferenceCollado-Vides, J., Magasanik, B., Gralla, J.D. ( 1991 ) Control site location and transcriptional regulation in Escherichia coli. Microbiol Rev 55: 371 – 394.en_US
dc.identifier.citedreferenceCrawford, J.A., Kaper, J.B., DiRita, V.J. ( 1998 ) Analysis of ToxR-dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae. Mol Microbiol 29: 235 – 246.en_US
dc.identifier.citedreferenceDiRita, V.J. & Mekalanos, J.J. ( 1991 ) Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation. Cell 64: 29 – 37.en_US
dc.identifier.citedreferenceDiRita, V.J., Parsot, C., Jander, G., Mekalanos, J.J. ( 1991 ) Regulatory cascade controls virulence in Vibrio cholerae. Proc Natl Acad Sci USA 88: 5403 – 5407.en_US
dc.identifier.citedreferenceDiRita, V.J., Neely, M., Taylor, R.K., Bruss, P.M. ( 1996 ) Differential expression of the ToxR regulon in classical and El Tor biotypes of Vibrio cholerae is due to biotype-specific control over toxT expression. Proc Natl Acad Sci USA 93: 7991 – 7995.en_US
dc.identifier.citedreferenceElliott, T. ( 1992 ) A method for constructing single-copy lac fusions in Salmonella typhimurium and its application to the hemA–prfA operon. J Bacteriol 174: 245 – 253.en_US
dc.identifier.citedreferenceFÜrste, J.P., Pansegrau, W., Frank, R., BlÖcker, H., Scholz, P., Bagdasarian, M., et al. ( 1986 ) Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector. Gene 48: 119 – 131.en_US
dc.identifier.citedreferenceHarlocker, S.L., Bergstrom, L., Inouye, M. ( 1995 ) Tandem binding of six OmpR proteins to the ompF upstream regulatory sequence of Escherichia coli. J Biol Chem 270: 26849 – 26856.en_US
dc.identifier.citedreferenceHÄse, C.C. & Mekalanos, J.J. ( 1998 ) TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci USA 95: 730 – 734.en_US
dc.identifier.citedreferenceHiggins, D.E. & DiRita, V.J. ( 1994 ) Transcriptional control of toxT, a regulatory gene in the ToxR regulon of Vibrio cholerae. Mol Microbiol 14: 17 – 29.en_US
dc.identifier.citedreferenceHiggins, D.E., Nazareno, E., DiRita, V.J. ( 1992 ) The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activators. J Bacteriol 174: 6974 – 6980.en_US
dc.identifier.citedreferenceHiguchi, R. ( 1990 ) Recombinant PCR. In PCR Protocols: a Guide to Methods and Applications. Innis, M.A., Gelfand, D.H., Sninsky, J.J., and White, T.J. (eds). San Diego: Academic Press, p. 177 – 183.en_US
dc.identifier.citedreferenceIshihama, A. ( 1992 ) Role of RNA polymerase a subunit in transcription activation. Mol Microbiol 6: 3283 – 3288.en_US
dc.identifier.citedreferenceKaraolis, D.K., Johnson, J.A., Bailey, C.C., Boedeker, E.C., Kaper, J.B., Reeves, P.R. ( 1998 ) A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains. Proc Natl Acad Sci USA 95: 3134 – 3139.en_US
dc.identifier.citedreferenceKaraolis, D.K.R., Somara, S., Manaeval, D.R., Jr, Johnson, J.A., Kaper, J.B. ( 1999 ) A bacteriophage encoding a pathogenicity island, a type-IV pilus and a phage receptor in cholera bacteria. Nature 399: 375 – 379.en_US
dc.identifier.citedreferenceKovach, M.E., Shaffer, M.D., Peterson, K.M. ( 1996 ) A putative integrase gene defines the distal end of a large cluster of ToxR-regulated colonization genes in Vibrio cholerae. Microbiology 142: 2165 – 2174.en_US
dc.identifier.citedreferenceKovacikova, G. & Skorupski, K. ( 1999 ) A Vibrio cholerae LysR homolog, AphB, cooperates with AphA at the tcpPH promoter to activate expression of the ToxR virulence cascade. J Bacteriol 181: 4250 – 4256.en_US
dc.identifier.citedreferenceLi, C.C., Crawford, J.A., DiRita, V.J., Kaper, J.B. ( 2000 ) Molecular cloning and transcriptional regulation of ompT, a ToxR-repressed gene in Vibrio cholerae. Mol Microbiol 35: 189 – 203.en_US
dc.identifier.citedreferenceMakino, K., Amemura, M., Kawamoto, T., Kimura, S., Shinagawa, H., Nabata, A., et al. ( 1996 ) DNA binding of PhoB and its interaction with RNA polymerase. J Mol Biol 259: 15 – 26.en_US
dc.identifier.citedreferenceMartÍnez-Hackert, E. & Stock, A.M. ( 1997a ) Structural relationships in the OmpR family of winged-helix transcription factors. J Mol Biol 269: 301 – 312.en_US
dc.identifier.citedreferenceMartÍnez-Hackert, E. & Stock, A.M. ( 1997b ) The DNA-binding domain of OmpR: crystal structure of a winged helix transcription factor. Structure 5: 109 – 124.en_US
dc.identifier.citedreferenceMiller, J.H. ( 1972 ) Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.en_US
dc.identifier.citedreferenceMiller, V.L. & Mekalanos, J.J. ( 1988 ) A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol 170: 2575 – 2583.en_US
dc.identifier.citedreferenceMiller, V.L., Taylor, R.K., Mekalanos, J.J. ( 1987 ) Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein. Cell 48: 271 – 279.en_US
dc.identifier.citedreferenceMurley, Y.M., Carroll, P.A., Skorupski, K., Taylor, R.K., Calderwood, S.B. ( 1999 ) Differential transcription of the tcpPH operon confers biotype-specific control of the Vibrio cholerae ToxR virulence regulon. Infect Immun 67: 5117 – 5123.en_US
dc.identifier.citedreferenceOgierman, M.A., Voss, E., Meaney, C., Faast, R., Attridge, S.R., Manning, P.A. ( 1996 ) Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and El Tor strains of Vibrio cholerae O1. Gene 170: 9 – 16.en_US
dc.identifier.citedreferenceOttemann, K.M., DiRita, V.J., Mekalanos, J.J. ( 1992 ) ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter. J Bacteriol 174: 6807 – 6814.en_US
dc.identifier.citedreferencePeterson, K.M. & Mekalanos, J.J. ( 1988 ) Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization. Infect Immun 56: 2822 – 2829.en_US
dc.identifier.citedreferencePratt, L.A. & Silhavy, T.J. ( 1994 ) OmpR mutants specifically defective for transcriptional activation. J Mol Biol 243: 579 – 594.en_US
dc.identifier.citedreferenceRhodius, V.A. & Busby, S.J.W. ( 1998 ) Positive activation of gene expression. Curr Opin Microbiol 1: 152 – 159.en_US
dc.identifier.citedreferenceRusso, F.D., Slauch, J.M., Silhavy, T.J. ( 1993 ) Mutations that affect separate functions of OmpR the phosphorylated regulator of porin transcription in Escherichia coli. J Mol Biol 231: 261 – 273.en_US
dc.identifier.citedreferenceSambrook, J., Fritsch, E.F., Maniatis, T. ( 1989 ) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.en_US
dc.identifier.citedreferenceSkorupski, K. & Taylor, R.K. ( 1996 ) Broad-host-range positive selection vectors for allelic exchange. Gene 169: 47 – 52.en_US
dc.identifier.citedreferenceSkorupski, K. & Taylor, R.K. ( 1999 ) A new level in the Vibrio cholerae virulence cascade: aphA is required for transcriptional activation of the tcpPH operon. Mol Microbiol 31: 763 – 771.en_US
dc.identifier.citedreferenceSvennerholm, A.M. & Holmgren, J. ( 1978 ) Identification of the Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM 1 -ELISA) procedure. Curr Microbiol 1: 19 – 23.en_US
dc.identifier.citedreferenceTaylor, R.K., Miller, V.L., Furlong, D.B., Mekalanos, J.J. ( 1987 ) Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. Proc Natl Acad Sci USA 84: 2833 – 2837.en_US
dc.identifier.citedreferenceThomas, S., Williams, S.G., Manning, P.A. ( 1995 ) Regulation of tcp genes in classical and El Tor strains of Vibrio cholerae O1. Gene 166: 43 – 48.en_US
dc.identifier.citedreferenceWaldor, M.K. & Mekalanos, J.J. ( 1996 ) Lysogenic conversion by a filamentous phage encoding cholera toxin. Science 272: 1910 – 1914.en_US
dc.identifier.citedreferenceWong, S.M., Carroll, P.A., Rahme, L.G., Ausubel, F.M., Calderwood, S.B. ( 1998 ) Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators. Infect Immun 66: 5854 – 5861.en_US
dc.identifier.citedreferenceYu, R.R. & DiRita, V.J. ( 1999 ) Analysis of an autoregulatory loop controlling ToxT, cholera toxin, and toxin-coregulated pilus production in Vibrio cholerae. J Bacteriol 181: 2584 – 2592.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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