View Item 

Show simple item record

Modulation of Intestinal Gas Dynamics in Healthy Human Volunteers by the 5-HT 4 Receptor Agonist Tegaserod
dc.contributor.authorColeski, Radoslaven_US
dc.contributor.authorOwyang, Chungen_US
dc.contributor.authorHasler, William L.en_US
dc.date.accessioned2010-06-01T22:15:46Z
dc.date.available2010-06-01T22:15:46Z
dc.date.issued2006-08en_US
dc.identifier.citationColeski, Radoslav; Owyang, Chung; Hasler, William L. (2006). "Modulation of Intestinal Gas Dynamics in Healthy Human Volunteers by the 5-HT 4 Receptor Agonist Tegaserod." The American Journal of Gastroenterology 101(8): 1858-1865. <http://hdl.handle.net/2027.42/75277>en_US
dc.identifier.issn0002-9270en_US
dc.identifier.issn1572-0241en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75277
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16817836&dopt=citationen_US
dc.format.extent167508 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Incen_US
dc.rights2006 by Am. Coll. of Gastroenterologyen_US
dc.titleModulation of Intestinal Gas Dynamics in Healthy Human Volunteers by the 5-HT 4 Receptor Agonist Tegaseroden_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.identifier.pmid16817836en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75277/1/j.1572-0241.2006.00708.x.pdf
dc.identifier.doi10.1111/j.1572-0241.2006.00708.xen_US
dc.identifier.sourceThe American Journal of Gastroenterologyen_US
dc.identifier.citedreferenceSandler RS, Stewart WF, Liberman JN, et al. Abdominal pain, bloating, and diarrhea in the United States: Prevalence and impact. Dig Dis Sci 2000; 45: 1166 – 71.en_US
dc.identifier.citedreferenceHahn B, Watson M, Yan S, et al. Irritable bowel syndrome symptom patterns: Frequency, duration, and severity. Dig Dis Sci 1998; 43: 2715 – 8.en_US
dc.identifier.citedreferenceLembo T, Naliboff B, Munakata J, et al. Symptoms and visceral perception in patients with pain-predominant irritable bowel syndrome. Am J Gastroenterol 1999; 94: 1320 – 6.en_US
dc.identifier.citedreferenceSerra J, Azpiroz F, Malagelada JR. Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome. Gut 2001; 48: 14 – 9.en_US
dc.identifier.citedreferenceSerra J, Salvioli B, Azpiroz F, et al. Lipid-induced intestinal gas retention in irritable bowel syndrome. Gastroenterology 2002; 123: 700 – 6.en_US
dc.identifier.citedreferenceCostall B, Naylor RJ, Tuladhar BR. 5-HT 4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum. Br J Pharmacol 1993; 110: 1572 – 8.en_US
dc.identifier.citedreferenceGrider JR, Kuemmerle JF, Jin JG. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT 4 /5-HT 1P receptors on sensory CGRP neurons. Am J Physiol 1996; 270: G778 – 82.en_US
dc.identifier.citedreferenceSherif A, Coleski R, Sun WM, et al. 5-HT 4 receptor stimulation of colonic peristaltic reflex and basal tonic colon activity by tegaserod in healthy humans: Possible mechanisms of its action in constipation (abstract). Gastroenterology 2004; 126: 109.en_US
dc.identifier.citedreferencePascual D, Alsasua A, Goicoechea C, et al. The involvement of 5-HT 3 and 5-HT 4 receptors in two models of gastrointestinal transit in mice. Neurosci Lett 2002; 326: 163 – 6.en_US
dc.identifier.citedreferenceHoughton LA, Jackson NA, Whorwell PJ, et al. 5-HT 4 receptor antagonism in irritable bowel syndrome: Effect of SB-207266-A on rectal sensitivity and small bowel transit. Aliment Pharmacol Ther 1999; 13: 1437 – 44.en_US
dc.identifier.citedreferencePrather CM, Camilleri M, Zinsmeister AR, et al. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology 2000; 118: 463 – 8.en_US
dc.identifier.citedreferenceMuller-Lissner SA, Fumagalli I, Bardhan KD, et al. Tegaserod, a 5-HT 4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther 2001; 15: 1655 – 66.en_US
dc.identifier.citedreferenceGonlachanvit S, Coleski R, Owyang C, et al. Inhibitory actions of a high fibre diet on intestinal gas transit in healthy volunteers. Gut 2004; 53: 1577 – 82.en_US
dc.identifier.citedreferenceAppel-Dingemanse S, Hirschberg Y, Osborne S, et al. Multiple-dose pharmacokinetics confirm no accumulation and dose proportionality of the novel promotile drug tegaserod (HTF 919). Eur J Clin Pharmacol 2001; 56: 889 – 91.en_US
dc.identifier.citedreferenceSerra J, Azpiroz F, Malagelada JR. Intestinal gas dynamics and tolerance in humans. Gastroenterology 1998; 115: 542 – 50.en_US
dc.identifier.citedreferenceLevitt MD. Follow-up of a flatulent patient. Dig Dis Sci 1979; 24: 652 – 4.en_US
dc.identifier.citedreferenceRamirez FC, Lee K, Graham DY. All lactase preparations are not the same: Results of a prospective, randomized, placebo-controlled trial. Am J Gastroenterol 1994; 89: 566 – 70.en_US
dc.identifier.citedreferenceJain NK, Patel VP, Pitchumoni CS. Efficacy of activated charcoal in reducing intestinal gas: A double-blind clinical trial. Am J Gastroenterol 1986; 81: 532 – 5.en_US
dc.identifier.citedreferenceLasser RB, Bond JH, Levitt MD. The role of intestinal gas in functional abdominal pain. N Engl J Med 1975; 293: 524 – 6.en_US
dc.identifier.citedreferenceGalati JS, McKee DP, Quigley EM. Response to intraluminal gas in irritable bowel syndrome. Motility versus perception. Dig Dis Sci 1995; 40: 1381 – 7.en_US
dc.identifier.citedreferenceGrider JR, Foxx-Orenstein AE, Jin JG. 5-Hydroxy-tryptamine 4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology 1998; 115: 370 – 80.en_US
dc.identifier.citedreferenceTuladhar BR, Costall B, Naylor RJ. 5-HT 3 and 5-HT 4 receptor-mediated facilitation of the emptying phase of the peristaltic reflex in the marmoset isolated ileum. Br J Pharmacol 1996; 117: 1679 – 84.en_US
dc.identifier.citedreferenceSims MA, Hasler WL, Chey WD, et al. Hyperglycemia inhibits mechanoreceptor-mediated gastrocolonic responses and colonic peristaltic reflexes in healthy humans. Gastroenterology 1995; 108: 350 – 9.en_US
dc.identifier.citedreferenceBjornsson ES, Chey WD, Ladabaum U, et al. Differential 5-HT 3 mediation of human gastrocolonic response and colonic peristaltic reflex. Am J Physiol 1998; 275: G498 – 505.en_US
dc.identifier.citedreferenceBjornsson ES, Chey WD, Hooper F, et al. Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: Role of 5-HT 3 pathways. Am J Physiol Gastrointest Liver Physiol 2002; 283: G400 – 7.en_US
dc.identifier.citedreferenceDegen L, Matzinger D, Merz M, et al. Tegaserod, a 5-HT 4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects. Aliment Pharmacol Ther 2001; 15: 1745 – 51.en_US
dc.identifier.citedreferenceCaldarella MP, Serra J, Azpiroz F, et al. Prokinetic effects in patients with intestinal gas retention. Gastroenterology 2002; 122: 1748 – 55.en_US
dc.identifier.citedreferenceGonlachanvit S, Coleski R, Hasler W. Luminal contents modulate intestinal gas transit in healthy humans: Effects of fiber vs. colonic lavage (abstract). Gastroenterology 2003; 124: T1802.en_US
dc.identifier.citedreferenceGonlachanvit S, Coleski R, Hasler W. Correlation of gas transit with small bowel motility during fasting and postprandial periods in healthy humans (abstract). Gastroenterology 2004; 126: 107.en_US
dc.identifier.citedreferenceTougas G, Snape WJ, Otten MH, et al. Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2002; 16: 1701 – 8.en_US
dc.identifier.citedreferenceGonlachanvit S, Coleski R, Hasler W. Nutrient modulation of intestinal gas dynamics in healthy humans depends on caloric content and physical properties (abstract). Gastroenterology 2003; 124: 307.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1572-0241.2006.00708.x.pdf
Size:
163.5KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.