Differences between smokers and never-smokers in sensitivity to nicotine: a preliminary report
dc.contributor.author | Pomerleau, Ovide F. | en_US |
dc.contributor.author | Hariharan, Meenatshisundanan | en_US |
dc.contributor.author | Pomerleau, Cynthia S. | en_US |
dc.contributor.author | Cameron, Oliver G. | en_US |
dc.contributor.author | Guthrie, Sally K. | en_US |
dc.date.accessioned | 2010-06-01T22:18:29Z | |
dc.date.available | 2010-06-01T22:18:29Z | |
dc.date.issued | 1993-01 | en_US |
dc.identifier.citation | POMERLEAU, OVIDE F.; HARIHARAN, M.; POMERLEAU, CYNTHIA S.; CAMERON, OLIVER G.; GUTHRIE, SALLY K. (1993). "Differences between smokers and never-smokers in sensitivity to nicotine: a preliminary report." Addiction 88(1): 113-118. <http://hdl.handle.net/2027.42/75319> | en_US |
dc.identifier.issn | 0965-2140 | en_US |
dc.identifier.issn | 1360-0443 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75319 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8448500&dopt=citation | en_US |
dc.description.abstract | Sensitivity to nicotine was explored using test doses administered via intra-nasal aerosol in 10 smokers and JO never-smokers. Smokers received 1.50 mg nicotine (in 2 sprays, < 5 seconds apart, one spray per nostril); never-smokers received either 0.50 mg (n = 3) or 0.25 (n = 7) nicotine. Accumulation of nicotine in plasma, per unit dose administered, was nearly four times greater in never-smokers, than in smokers, indicating differences in pharmacokinetic tolerance. To examine sensitivity to nicotine without this confound, peak physiological reactivity (heart rate and blood pressure changes) was divided by peak plasma nicotine increment and the ratio was expressed as a function of cotinine level prior to dosing, thereby relating sensitivity to nicotine to history of exposure. In smokers, functional sensitivity to nicotine was inversely related to customary nicotine intake, replicating previous findings for light and heavy smokers. The observation that never-smokers were not much more sensitive to nicotine than light smokers is notable given the disparity in previous history of exposure. | en_US |
dc.format.extent | 1190966 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1993 Society for the Study of Addiction to Alcohol and Other Drugs | en_US |
dc.title | Differences between smokers and never-smokers in sensitivity to nicotine: a preliminary report | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Behavioral Medicine Program, Department of Psychiatry, University of Michigan School of Medicine, 475 Market Place, Suite L, Ann Arbor, MI 48108, USA | en_US |
dc.identifier.pmid | 8448500 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75319/1/j.1360-0443.1993.tb02768.x.pdf | |
dc.identifier.doi | 10.1111/j.1360-0443.1993.tb02768.x | en_US |
dc.identifier.source | Addiction | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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