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Interleukin-1β modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation
dc.contributor.authorAlam, Md. Nooren_US
dc.contributor.authorMcGinty, Dennisen_US
dc.contributor.authorBashir, Tariqen_US
dc.contributor.authorKumar, Sunilen_US
dc.contributor.authorImeri, Lucaen_US
dc.contributor.authorOpp, Mark R.en_US
dc.contributor.authorSzymusiak, Ronalden_US
dc.date.accessioned2010-06-01T22:24:23Z
dc.date.available2010-06-01T22:24:23Z
dc.date.issued2004-07en_US
dc.identifier.citationAlam, Md. Noor; McGinty, Dennis; Bashir, Tariq; Kumar, Sunil; Imeri, Luca; Opp, Mark R.; Szymusiak, Ronald (2004). "Interleukin-1β modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation." European Journal of Neuroscience 20(1): 207-216. <http://hdl.handle.net/2027.42/75399>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75399
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15245493&dopt=citationen_US
dc.description.abstractInterleukin-1β (IL-1) is a pro-inflammatory cytokine that has been implicated in the regulation of nonrapid eye movement (nonREM) sleep. IL-1, IL-1 receptors and the IL-1 receptor antagonist (ra) are present normally in discrete brain regions, including the preoptic area (POA) of the hypothalamus and the adjoining magnocellular basal forebrain (BF). The POA/BF have been implicated in the regulation of sleep–wakefulness. We hypothesized that IL-1 promotes nonREM sleep, in part by altering the state-dependent discharge activity of POA/BF neurons. We recorded the sleep–wake discharge profiles of 83 neurons in the lateral POA/BF and assessed the effects of IL-1, IL-1ra, and IL-ra + IL-1 delivered through a microdialysis probe on state-dependent neuronal discharge activity. IL-1 decreased the discharge rate of POA/BF neurons as a group ( n  = 55) but wake-related and sleep-related neurons responded differently. IL-1 significantly decreased the discharge rate of wake-related neurons. Of 24 wake-related neurons studied, 19 (79%) neurons exhibited a greater than 20% change in their discharge in the presence of IL-1 during waking. IL-1 suppressed the discharge activity of 18 of 19 responsive neurons. Of 13 sleep-related neurons studied, IL-1 increased the discharge activity of five and suppressed the discharge activity of four neurons. IL-1ra increased the discharge activity of four of nine neurons and significantly attenuated IL-1-induced effects on neuronal activity of POA/BF neurons ( n  = 19). These results suggest that the sleep-promoting effects of IL-1 may be mediated, in part, via the suppression of wake-related neurons and the activation of a subpopulation of sleep-related neurons in the POA/BF.en_US
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dc.publisherBlackwell Science Ltden_US
dc.rights2004 Federation of European Neuroscience Societiesen_US
dc.subject.otherCytokineen_US
dc.subject.otherExtracellular Unit Recordingen_US
dc.subject.otherInterleukin-1 Receptor Antagonisten_US
dc.subject.otherMicrodialysisen_US
dc.subject.otherRaten_US
dc.titleInterleukin-1β modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulationen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Anesthesiology and Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherVeteran Affairs Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91343, USAen_US
dc.contributor.affiliationotherDepartment of Psychologyen_US
dc.contributor.affiliationotherDepartment of Medicine, University of California, Los Angeles, CA 90033, USAen_US
dc.contributor.affiliationotherInstitute of Human Physiology II, University of Milan, Milan, Italyen_US
dc.identifier.pmid15245493en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75399/1/j.1460-9568.2004.03469.x.pdf
dc.identifier.doi10.1111/j.1460-9568.2004.03469.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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