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The role of T helper type 17 cells in inflammatory arthritis
dc.contributor.authorSarkar, S.en_US
dc.contributor.authorCooney, L. A.en_US
dc.contributor.authorFox, D. A.en_US
dc.date.accessioned2010-06-01T22:27:34Z
dc.date.available2010-06-01T22:27:34Z
dc.date.issued2010-03en_US
dc.identifier.citationSarkar, S.; Cooney, L. A.; Fox, D. A. (2010). "The role of T helper type 17 cells in inflammatory arthritis." Clinical & Experimental Immunology 159(3): 225-237. <http://hdl.handle.net/2027.42/75449>en_US
dc.identifier.issn0009-9104en_US
dc.identifier.issn1365-2249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75449
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19758374&dopt=citationen_US
dc.description.abstractWhile T cells have been implicated in the pathogenesis of inflammatory arthritis for more than three decades, the focus on the T helper type 17 (Th17) subset of CD4 T cells and their secreted cytokines, such as interleukin (IL)-17, is much more recent. Proinflammatory actions of IL-17 were first identified in the 1990s, but the delineation of a distinct Th17 subset in late 2005 has sparked great interest in the role of these cells in a broad range of immune-mediated diseases. This review summarizes current understanding of the role of Th17 cells and their products in both animal models of inflammatory arthritis and human immune-driven arthritides.en_US
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dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsJournal Compilation © 2010 British Society for Immunologyen_US
dc.subject.otherCollagen Arthritisen_US
dc.subject.otherCytokinesen_US
dc.subject.otherRheumatoid Arthritisen_US
dc.subject.otherSpondyloarthritisen_US
dc.subject.otherT Lymphocytesen_US
dc.titleThe role of T helper type 17 cells in inflammatory arthritisen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumProgram in Immunology and Rheumatic Diseases Research Core Center, University of Michigan Division of Rheumatology, Ann Arbor, MI, USAen_US
dc.contributor.affiliationother* Department of Medicine, Section of Rheumatology, University of Arizona Tucson, AZ, anden_US
dc.identifier.pmid19758374en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75449/1/j.1365-2249.2009.04016.x.pdf
dc.identifier.doi10.1111/j.1365-2249.2009.04016.xen_US
dc.identifier.sourceClinical & Experimental Immunologyen_US
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