Comorbid illness is an important determinant of health-related quality of life in patients with chronic hepatitis C
dc.contributor.author | Hussain, Khozema B. | en_US |
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Moyer, Cheryl A. | en_US |
dc.contributor.author | Su, Grace L. | en_US |
dc.contributor.author | Sneed-Pee, Naomi | en_US |
dc.contributor.author | Lok, Anna Suk-Fong | en_US |
dc.date.accessioned | 2010-06-01T22:35:24Z | |
dc.date.available | 2010-06-01T22:35:24Z | |
dc.date.issued | 2001-09 | en_US |
dc.identifier.citation | Hussain, Khozema B . ; Fontana, Robert J . ; Moyer, Cheryl A . ; Su, Grace L . ; Sneed-Pee, Naomi; Lok, Anna S.F . (2001). "Comorbid illness is an important determinant of health-related quality of life in patients with chronic hepatitis C." The American Journal of Gastroenterology 96(9): 2737-2744. <http://hdl.handle.net/2027.42/75569> | en_US |
dc.identifier.issn | 0002-9270 | en_US |
dc.identifier.issn | 1572-0241 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75569 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11569704&dopt=citation | en_US |
dc.description.abstract | Chronic hepatitis C (CHC) patients selected for entry into treatment trials have been reported to have impaired health-related quality of life (HRQOL). However, these trials have an inherent selection bias, and HRQOL in CHC patients may have been underestimated because of the exclusion of patients with comorbid illness. The aim of this study was to assess HRQOL in an unselected group of CHC patients and to identify factors associated with impairment in HRQOL. METHODS : A total of 220 consecutive eligible CHC patients were enrolled from a hepatology clinic. HRQOL was assessed by the short form 36 (SF-36) and comorbid illnesses were assessed by an interview. RESULTS : CHC patients had significantly lower SF-36 scores in all subscales and in the summary scales when compared to those of the healthy general population in the United States ( p < 0.001 ). Compared to CHC patients entering treatment trials, our patients had lower SF-36 scores on five subscales ( p < 0.001 ). The presence of comorbid illness was the most important predictor of HRQOL in CHC patients. However, CHC alone resulted in significantly lower SF-36 scores in all subscales and summary scales ( p ≤ 0.003 ) compared to those of the healthy U.S. population. There was no correlation between SF-36 scores and history of i.v. drug use or dependence, alcohol dependence, and serum aminotransferase levels. CONCLUSIONS : We conclude that unselected CHC patients presenting for medical evaluation have a reduced HRQOL, which is lower than that reported for CHC patients entering treatment trials. CHC alone is associated with significant impairment in HRQOL, but the presence of comorbid illness leads to further diminution in HRQOL. | en_US |
dc.format.extent | 312102 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2001 by Am. Coll. of Gastroenterology | en_US |
dc.title | Comorbid illness is an important determinant of health-related quality of life in patients with chronic hepatitis C | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Consortium for Health Outcomes Innovations and Cost-effectiveness Studies (CHOICES), University of Michigan Health System, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 11569704 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75569/1/j.1572-0241.2001.04133.x.pdf | |
dc.identifier.doi | 10.1111/j.1572-0241.2001.04133.x | en_US |
dc.identifier.source | The American Journal of Gastroenterology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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