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Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: results from the National Hemochromatosis Transplant Registry
dc.contributor.authorKo, Cynthiaen_US
dc.contributor.authorSiddaiah, Narendraen_US
dc.contributor.authorBerger, Joseen_US
dc.contributor.authorGish, Robert G.en_US
dc.contributor.authorBrandhagen, Daviden_US
dc.contributor.authorSterling, Richard K.en_US
dc.contributor.authorCotler, Scott J.en_US
dc.contributor.authorFontana, Robert Johnen_US
dc.contributor.authorMcCashland, Timothy M.en_US
dc.contributor.authorHan, Steven-Huy B.en_US
dc.contributor.authorGordon, Frederic D.en_US
dc.contributor.authorSchilsky, Michael L.en_US
dc.contributor.authorKowdley, Kris V.en_US
dc.date.accessioned2010-06-01T22:35:43Z
dc.date.available2010-06-01T22:35:43Z
dc.date.issued2007-12en_US
dc.identifier.citationKo, Cynthia; Siddaiah, Narendra; Berger, Jose; Gish, Robert; Brandhagen, David; Sterling, Richard K.; Cotler, Scott J.; Fontana, Robert J.; McCashland, Timothy M.; Han, Steven H. B.; Gordon, Frederic D.; Schilsky, Michael L.; Kowdley, Kris V. (2007). "Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: results from the National Hemochromatosis Transplant Registry." Liver International 27(10): 1394-1401. <http://hdl.handle.net/2027.42/75573>en_US
dc.identifier.issn1478-3223en_US
dc.identifier.issn1478-3231en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75573
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17927713&dopt=citationen_US
dc.description.abstractBackground : It is unclear whether mild to moderate iron overload in liver diseases other than hereditary haemochromatosis (HH) contributes to hepatocellular carcinoma. This study examined the association between hepatic iron grade and hepatocellular carcinoma in patients with end-stage liver disease of diverse aetiologies. Methods : The prevalence of hepatic iron overload and hepatocellular carcinoma was examined in 5224 patients undergoing liver transplantation. Explant pathology reports were reviewed for the underlying pathological diagnosis, presence of hepatocellular carcinoma and degree of iron staining. The distribution of categorical variables was studied using Χ 2 tests. Results : Both iron overload and hepatocellular carcinoma were the least common with biliary cirrhosis (1.8 and 2.8% respectively). Hepatocellular carcinoma was the most common in patients with hepatitis B (16.7%), followed by those with hepatitis C (15.1%) and HH (14.9%). In the overall cohort, any iron overload was significantly associated with hepatocellular carcinoma ( P =0.001), even after adjustment for the underlying aetiology of liver disease. The association between hepatic iron content and hepatocellular carcinoma was the strongest in patients with biliary cirrhosis ( P <0.001) and hepatitis C ( P <0.001). Conclusions : Iron overload is associated with hepatocellular carcinoma in patients with end-stage liver disease, suggesting a possible carcinogenic or cocarcinogenic role for iron in chronic liver disease.en_US
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dc.format.extent3109 bytes
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dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2007 Blackwell Munksgaarden_US
dc.subject.otherCirrhosisen_US
dc.subject.otherHepatocellular Carcinomaen_US
dc.subject.otherIron Overloaden_US
dc.subject.otherLiver Transplantationen_US
dc.titlePrevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: results from the National Hemochromatosis Transplant Registryen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum7 University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationother1 Division of Gastroenterology, University of Washington Medical Center, Seattle, WA, USAen_US
dc.contributor.affiliationother2 Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS, USAen_US
dc.contributor.affiliationother3 California Pacific Medical Center, San Francisco, CA, USAen_US
dc.contributor.affiliationother4 Mayo Clinic College of Medicine, Rochester, MI, USAen_US
dc.contributor.affiliationother5 Virginia Commonwealth University, Richmond, VA, USAen_US
dc.contributor.affiliationother6 University of Illinois at Chicago, Chicago, IL, USAen_US
dc.contributor.affiliationother8 University of Nebraska Medical Center, Omaha, NE, USAen_US
dc.contributor.affiliationother9 University of California, Los Angeles, CA, USAen_US
dc.contributor.affiliationother10 Lahey Clinic Medical Center, Burlington, MA, USAen_US
dc.contributor.affiliationother11 New York Weill Cornell Medical Center, New York, NY, USAen_US
dc.contributor.affiliationother12 Benaroya Research Institute and Virginia Mason Medical Center, Seattle, WA, USAen_US
dc.identifier.pmid17927713en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75573/1/j.1478-3231.2007.01596.x.pdf
dc.identifier.doi10.1111/j.1478-3231.2007.01596.xen_US
dc.identifier.sourceLiver Internationalen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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