Efficiency of split-mouth designs
dc.contributor.author | Hujoel, Philippe P. | en_US |
dc.contributor.author | Loesche, Walter J. | en_US |
dc.date.accessioned | 2010-06-01T22:43:57Z | |
dc.date.available | 2010-06-01T22:43:57Z | |
dc.date.issued | 1990-11 | en_US |
dc.identifier.citation | Hujoel, P. P.; Loesche, W. J. (1990). "Efficiency of split-mouth designs." Journal of Clinical Periodontology 17(10): 722-728. <http://hdl.handle.net/2027.42/75701> | en_US |
dc.identifier.issn | 0303-6979 | en_US |
dc.identifier.issn | 1600-051X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75701 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2262586&dopt=citation | en_US |
dc.description.abstract | . The purpose of this paper is (1) to investigate the similarity of the amount, distribution, and, severity of periodontal disease of the within-patient experimental units, (2) to estimate the relative efficiencies of split-mouth designs when compared to whole-mouth designs, and (3) to discuss how stratification on initial pocket depth can result in large differences in the power of the test-statistics in the different disease categories. Periodontal disease characteristics are not always homogeneously distributed over the within-patient experimental units and this heterogeneity can reduce the efficiency of split-mouth designs. In particular, if analyses are stratified on initial pocket depth, sites with an initial probing depth deeper than 6 mm may be small in number and asymmetrically distributed when compared to sites with an initial probing depth less than 6 mm. This may result in large differences of the power of the test statistics among the different disease categories and should lead to a careful interpretation of the statistical significance tests. When disease characteristics are symmetrically distributed over the within-patient experimental units and a sufficient number of sites is present per experimental unit, the split-mouth design can provide moderate to large gains in relative efficiency. In the absence of a symmetric disease distribution, wholemouth clinical trials may be preferable. | en_US |
dc.format.extent | 8124839 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1990 Munksgaard | en_US |
dc.subject.other | Split-mouth Design | en_US |
dc.subject.other | Clinical Trials | en_US |
dc.subject.other | Uniformity Trial | en_US |
dc.subject.other | Efficiency | en_US |
dc.subject.other | Similarity | en_US |
dc.subject.other | Suitability | en_US |
dc.title | Efficiency of split-mouth designs | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Material Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biostatistics, School of Public Health, University of Michigan, 109 South Observatory, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 2262586 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75701/1/j.1600-051X.1990.tb01060.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-051X.1990.tb01060.x | en_US |
dc.identifier.source | Journal of Clinical Periodontology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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