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EFFECT OF CORTISOL TREATMENT ON HORMONAL RELATIONSHIPS IN CONGENITAL ADRENAL HYPERPLASIA

dc.contributor.authorBacon, George E.en_US
dc.contributor.authorSpencer, Martha L.en_US
dc.contributor.authorKelch, Robert P.en_US
dc.date.accessioned2010-06-01T22:44:44Z
dc.date.available2010-06-01T22:44:44Z
dc.date.issued1977-02en_US
dc.identifier.citationBACON, GEORGE E.; SPENCER, MARTHA L.; KELCH, ROBERT P. (1977). "EFFECT OF CORTISOL TREATMENT ON HORMONAL RELATIONSHIPS IN CONGENITAL ADRENAL HYPERPLASIA." Clinical Endocrinology 6(2): 113-126. <http://hdl.handle.net/2027.42/75713>en_US
dc.identifier.issn0300-0664en_US
dc.identifier.issn1365-2265en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75713
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=844219&dopt=citationen_US
dc.description.abstractThe temporal relationship between administration of cortisol and serum 17Α-hydroxyprogesterone was investigated in five patients aged 9-19 years with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. There was marked variability in the 17Α-hydroxyprogesterone response (determined hourly for 24 h) of individual patients to administration of cortisol. Mean concentration was less than 0.030 Μmol/l in one patient but 0.519Μ mol/l in another. Levels were higher in all patients while off treatment, and were greatest in those with salt-losing adrenal hyperplasia. Growth hormone secretion was not suppressed by treatment with cortisol. Withdrawal of cortisol for 3 days resulted in a significant decrease in the mean serum FSH/LH ratio and a rise in serum testosterone in all subjects. Episodic release of gonadotrophins persisted in the adolescent patients.en_US
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dc.format.extent3109 bytes
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1977 Blackwell Scientific Publicationsen_US
dc.titleEFFECT OF CORTISOL TREATMENT ON HORMONAL RELATIONSHIPS IN CONGENITAL ADRENAL HYPERPLASIAen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, Michiganen_US
dc.identifier.pmid844219en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75713/1/j.1365-2265.1977.tb02002.x.pdf
dc.identifier.doi10.1111/j.1365-2265.1977.tb02002.xen_US
dc.identifier.sourceClinical Endocrinologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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