Duplication 16p11.2 in a child with infantile seizure disorder
dc.contributor.author | Bedoyan, Jirair K. | en_US |
dc.contributor.author | Kumar, Ravinesh A. | en_US |
dc.contributor.author | Sudi, Jyotsna | en_US |
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.contributor.author | Ackley, Todd | en_US |
dc.contributor.author | Iyer, Ramaswamy K. | en_US |
dc.contributor.author | Christian, Susan L. | en_US |
dc.contributor.author | Martin, Donna M. | en_US |
dc.date.accessioned | 2010-06-02T19:49:11Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-06 | en_US |
dc.identifier.citation | Bedoyan, Jirair K.; Kumar, Ravinesh A.; Sudi, Jyotsna; Silverstein, Faye; Ackley, Todd; Iyer, Ramaswamy K.; Christian, Susan L.; Martin, Donna M. (2010). "Duplication 16p11.2 in a child with infantile seizure disorder." American Journal of Medical Genetics Part A 152A(6): 1567-1574. <http://hdl.handle.net/2027.42/75769> | en_US |
dc.identifier.issn | 1552-4825 | en_US |
dc.identifier.issn | 1552-4833 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75769 | |
dc.description.abstract | Submicroscopic recurrent 16p11.2 rearrangements are associated with several neurodevelopmental disorders, including autism, mental retardation, and schizophrenia. The common 16p11.2 region includes 24 known genes, of which 22 are expressed in the developing human fetal nervous system. As yet, the mechanisms leading to neurodevelopmental abnormalities and the broader phenotypes associated with deletion or duplication of 16p11.2 have not been clarified. Here we report a child with spastic quadriparesis, refractory infantile seizures, severe global developmental delay, hypotonia, and microcephaly, and a de novo 598 kb 16p11.2 microduplication. Family history is negative for any of these features in parents and immediate family members. Sequencing analyses showed no mutations in DOC2A , QPRT , and SEZ6L2 , genes within the duplicated 16p11.2 region that have been implicated in neuronal function and/or seizure related phenotypes. The child's clinical course is consistent with a rare seizure disorder called malignant migrating partial seizure disorder of infancy, raising the possibility that duplication or disruption of genes in the 16p11.2 interval may contribute to this severe disorder. © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 283825 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Duplication 16p11.2 in a child with infantile seizure disorder | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan ; Department of Pathology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, The University of Michigan, Ann Arbor, Michigan ; Associate Professor, Departments of Pediatrics and Human Genetics, University of Michigan, 3520A MSRB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-5652. | en_US |
dc.contributor.affiliationother | Department of Human Genetics, The University of Chicago, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Department of Human Genetics, The University of Chicago, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Department of Human Genetics, The University of Chicago, Chicago, Illinois | en_US |
dc.identifier.pmid | 20503337 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75769/1/33415_ftp.pdf | |
dc.identifier.doi | 10.1002/ajmg.a.33415 | en_US |
dc.identifier.source | American Journal of Medical Genetics Part A | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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