Prognostic significance of regulatory T cells in tumor
dc.contributor.author | Wilke, Cailin Moira | en_US |
dc.contributor.author | Wu, Ke | en_US |
dc.contributor.author | Zhao, Ende | en_US |
dc.contributor.author | Wang, Guobin | en_US |
dc.contributor.author | Zou, Weiping | en_US |
dc.date.accessioned | 2010-07-06T14:28:51Z | |
dc.date.available | 2011-03-01T16:26:47Z | en_US |
dc.date.issued | 2010-08-15 | en_US |
dc.identifier.citation | Wilke, Cailin Moira; Wu, Ke; Zhao, Ende; Wang, Guobin; Zou, Weiping (2010). "Prognostic significance of regulatory T cells in tumor." International Journal of Cancer 127(4): 748-758. <http://hdl.handle.net/2027.42/77441> | en_US |
dc.identifier.issn | 0020-7136 | en_US |
dc.identifier.issn | 1097-0215 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77441 | |
dc.description.abstract | Since entering the immunological stage several decades ago, regulatory T cell biology has been realized as fundamentally important in the prevention of autoimmune conditions, induction of transplant tolerance and the immune response to cancer. The role of regulatory T cells in tumor immunobiology is still being elucidated. Currently, regulatory T cells are implicated in the dampening of antitumor T-cell responses both through direct and indirect means. A number of investigators have demonstrated that regulatory T cell density and location may serve as independent prognostic factors in several types of cancer and are alternately detrimental or beneficial to patient survival. In this article, we will review the characteristics and functional phenotype of classical regulatory T cells, describe their distribution and quantification in tumor-bearing hosts and summarize recent studies investigating the prognostic significance of regulatory T cell number and locality in various cancers. | en_US |
dc.format.extent | 190287 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Prognostic significance of regulatory T cells in tumor | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Graduate Program in Immunology, University of Michigan, Ann Arbor, MI ; Department of Surgery, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, MI ; Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | en_US |
dc.contributor.affiliationum | Graduate Program in Immunology, University of Michigan, Ann Arbor, MI ; Department of Surgery, University of Michigan, Ann Arbor, MI ; Tel.: 734-615-5554 ; University of Michigan School of Medicine, C560B MSRB II, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-0669, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | en_US |
dc.contributor.affiliationother | Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | en_US |
dc.identifier.pmid | 20473951 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77441/1/25464_ftp.pdf | |
dc.identifier.doi | 10.1002/ijc.25464 | en_US |
dc.identifier.source | International Journal of Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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