Case Report: The Effect of Proton Pump Inhibitor Administration on Hemodynamics in a Cardiac Intensive Care Unit
dc.contributor.author | Booher, Anna M. | en_US |
dc.contributor.author | Dorsch, Michael P. | en_US |
dc.contributor.author | Gurm, Hitinder S. | en_US |
dc.date.accessioned | 2010-07-06T14:29:10Z | |
dc.date.available | 2011-03-01T16:26:47Z | en_US |
dc.date.issued | 2010-06 | en_US |
dc.identifier.citation | Booher, Anna M.; Dorsch, Michael; Gurm, Hitinder S. (2010). "Case Report: The Effect of Proton Pump Inhibitor Administration on Hemodynamics in a Cardiac Intensive Care Unit." Clinical Cardiology 33(6): E111-E113. <http://hdl.handle.net/2027.42/77444> | en_US |
dc.identifier.issn | 0160-9289 | en_US |
dc.identifier.issn | 1932-8737 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77444 | |
dc.description.abstract | Ex vivostudies have suggested that high dose proton pump inhibitors (PPI) may have negative inotropic effects in myocardial tissue. We sought to investigate this concept in a real-world clinical setting. In this case series, we enrolled critically ill patients in the coronary and cardiothoracic intensive care units who had a preexisting pulmonary artery (PA) catheter in place for hemodynamic monitoring and were on a PPI for prespecified clinical indications. Hemodynamic measurements were made at baseline and then at 15 minute intervals for 1 hour after PPI administration. A total of 18 patients were evaluated; 72% were male with a mean age of 59.9 years. A total of 9 patients were evaluated on 2 consecutive days, yielding 26 patient-exposures to the medication. The majority of patients (72%) were receiving 1 or more inotropic agents (n= 6), a vasopressor (n= 4), or both (n= 4). When compared to baseline values, there was no significant change in mean arterial pressure (baseline 80 ± 11 mm Hg), heart rate (87 ± 11 bpm), or Fick cardiac index (2.7 ± 1.8 L/min/m 2 ). Mean PA pressure did decrease transiently at 45 minutes following PPI administration (28.5 ± 7.7 mm Hg at baseline vs 26.5 ± 7.5 mm Hg, P = 0.017), but is unlikely to be of clinical significance. In conclusion, these data suggest that IV PPIs do not immediately impact important hemodynamic parameters and are likely safe in a high-risk intensive care setting. Copyright © 2010 Wiley Periodicals, Inc. | en_US |
dc.format.extent | 109920 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Medicine and Healthcare | en_US |
dc.subject.other | Cardiovascular Disease | en_US |
dc.title | Case Report: The Effect of Proton Pump Inhibitor Administration on Hemodynamics in a Cardiac Intensive Care Unit | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialities | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan ; University of Michigan Cardiovascular Center 1500 E. Medical Center Drive Ann Arbor, MI 48109-5853. | en_US |
dc.contributor.affiliationum | Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan ; Ann Arbor VA Medical Center, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 20552629 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77444/1/20690_ftp.pdf | |
dc.identifier.doi | 10.1002/clc.20690 | en_US |
dc.identifier.source | Clinical Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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