Comparison of characteristics from White- and Black-Americans with venous thromboembolism: A cross-sectional study
dc.contributor.author | Heit, John A. | en_US |
dc.contributor.author | Beckman, Michele G. | en_US |
dc.contributor.author | Bockenstedt, Paula L. | en_US |
dc.contributor.author | Grant, Althea M. | en_US |
dc.contributor.author | Key, Nigel S. | en_US |
dc.contributor.author | Kulkarni, Roshni | en_US |
dc.contributor.author | Manco-Johnson, Marilyn J. | en_US |
dc.contributor.author | Moll, Stephan | en_US |
dc.contributor.author | Ortel, Thomas L. | en_US |
dc.contributor.author | Philipp, Claire S. | en_US |
dc.date.accessioned | 2010-07-06T14:29:59Z | |
dc.date.available | 2011-03-01T16:26:48Z | en_US |
dc.date.issued | 2010-07 | en_US |
dc.identifier.citation | Heit, John A.; Beckman, Michele G.; Bockenstedt, Paula L.; Grant, Althea M.; Key, Nigel S.; Kulkarni, Roshni; Manco-Johnson, Marilyn J.; Moll, Stephan; Ortel, Thomas L.; Philipp, Claire S. (2010). "Comparison of characteristics from White- and Black-Americans with venous thromboembolism: A cross-sectional study." American Journal of Hematology 85(7): 467-471. <http://hdl.handle.net/2027.42/77452> | en_US |
dc.identifier.issn | 0361-8609 | en_US |
dc.identifier.issn | 1096-8652 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77452 | |
dc.description.abstract | When compared with Whites, Black-Americans may have a 40% higher incidence venous thromboembolism (VTE) incidence. However, whether other VTE characteristics and risk factors vary by race is uncertain. To compare demographic and baseline characteristics among White- and Black-Americans with VTE, we used data prospectively collected from consecutive consenting adults enrolled in seven Centers for Disease Control (CDC) Thrombosis and Hemostasis Centers from August 2003 to March 2009. These characteristics were compared among Whites ( n = 2002) and Blacks ( n = 395) with objectively diagnosed VTE, both overall, and by age and gender. When compared with Whites, Blacks had a significantly higher proportion with pulmonary embolism (PE), including idiopathic PE among Black women, and a significantly higher proportion of Blacks were women. Blacks had a significantly higher mean BMI and a significantly lower proportion with recent surgery, trauma or infection, family history of VTE, and documented thrombophilia (solely from reduced factor V Leiden and prothrombin G20210A prevalence). Conversely, Blacks had a significantly higher proportion with hypertension, diabetes mellitus, chronic renal disease and dialysis, HIV, and sickle cell disease. When compared with White women, Black women had a significantly lower proportion with recent oral contraceptive use or hormone therapy. We conclude that Whites and Blacks differ significantly regarding demographic and baseline characteristics that may be risk factors for VTE. The prevalence of transient VTE risk factors and idiopathic VTE among Blacks appears to be lower and higher, respectively, suggesting that heritability may be important in the etiology of VTE among Black-Americans. Am. J.Hematol. 85:467–471, 2010 © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 101167 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Comparison of characteristics from White- and Black-Americans with venous thromboembolism: A cross-sectional study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Hemophilia and Coagulation Disorders Program, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Mayo Clinic Thrombophilia Center, Mayo Clinic, Rochester, Minnesota ; Stabile 6-Hematology Research, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905 | en_US |
dc.contributor.affiliationother | Division of Blood Disorders, NCBDDD, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia | en_US |
dc.contributor.affiliationother | Division of Blood Disorders, NCBDDD, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia | en_US |
dc.contributor.affiliationother | Thrombophilia Program, UNC, Chapel Hill, North Carolina | en_US |
dc.contributor.affiliationother | Michigan State University Comprehensive Center for Bleeding Disorders, East Lansing, Michigan | en_US |
dc.contributor.affiliationother | Mountain States Regional Hemophilia and Thrombosis Center, Aurora, Colorado | en_US |
dc.contributor.affiliationother | Thrombophilia Program, UNC, Chapel Hill, North Carolina | en_US |
dc.contributor.affiliationother | Duke Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, North Carolina | en_US |
dc.contributor.affiliationother | Thrombosis Center, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey | en_US |
dc.identifier.pmid | 20575037 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77452/1/21735_ftp.pdf | |
dc.identifier.doi | 10.1002/ajh.21735 | en_US |
dc.identifier.source | American Journal of Hematology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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