Chemotherapy alone for organ preservation in advanced laryngeal cancer
dc.contributor.author | Divi, Vasu | en_US |
dc.contributor.author | Worden, Francis P. | en_US |
dc.contributor.author | Prince, Mark E. P. | en_US |
dc.contributor.author | Eisbruch, Avraham | en_US |
dc.contributor.author | Lee, Julia S. | en_US |
dc.contributor.author | Bradford, Carol R. | en_US |
dc.contributor.author | Chepeha, Douglas B. | en_US |
dc.contributor.author | Teknos, Theodoros N. | en_US |
dc.contributor.author | Hogikyan, Norman D. | en_US |
dc.contributor.author | Moyer, Jeffrey S. | en_US |
dc.contributor.author | Tsien, Christina I. | en_US |
dc.contributor.author | Urba, Susan G. | en_US |
dc.contributor.author | Wolf, Gregory T. | en_US |
dc.date.accessioned | 2010-08-02T17:46:35Z | |
dc.date.available | 2011-03-01T16:26:47Z | en_US |
dc.date.issued | 2010-08 | en_US |
dc.identifier.citation | Divi, Vasu; Worden, Francis P.; Prince, Mark E.; Eisbruch, Avraham; Lee, Julia S.; Bradford, Carol R.; Chepeha, Douglas B.; Teknos, Theodoros N.; Hogikyan, Norman D.; Moyer, Jeffrey S.; Tsien, Christina I.; Urba, Susan G.; Wolf, Gregory T. (2010). "Chemotherapy alone for organ preservation in advanced laryngeal cancer." Head & Neck 32(8): 1040-1047. <http://hdl.handle.net/2027.42/77508> | en_US |
dc.identifier.issn | 1043-3074 | en_US |
dc.identifier.issn | 1097-0347 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77508 | |
dc.description.abstract | Background. For patients with advanced laryngeal cancer, a trial was designed to determine if chemotherapy alone, in patients achieving a complete histologic complete response after a single neoadjuvant cycle, was an effective treatment with less morbidity than concurrent chemoradiotherapy. Methods. Thirty-two patients with advanced laryngeal or hypopharyngeal cancer received 1 cycle of induction chemotherapy, and subsequent treatment was decided based on response. Results. A histologic complete response was achieved in 4 patients and were treated with chemotherapy alone. All 4 patients' cancer relapsed in the neck and required surgery and postoperative radiotherapy (RT). Twenty-five patients were treated with concomitant chemoradiation. Three patients were treated with surgery. Overall survival and disease-specific survival at 3 years were 68% and 78%, respectively. Conclusion. Chemotherapy alone is not feasible for long-term control of regional disease in patients with advanced laryngeal cancer even when they achieve a histologic complete response at the primary site. © 2009 Wiley Periodicals, Inc. Head Neck, 2010 | en_US |
dc.format.extent | 517865 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Chemotherapy alone for organ preservation in advanced laryngeal cancer | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Vasu Divi and Francis P. Worden contributed equally to this work. | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI ; Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.identifier.pmid | 19953609 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77508/1/21285_ftp.pdf | |
dc.identifier.doi | 10.1002/hed.21285 | en_US |
dc.identifier.source | Head & Neck | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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