Gender differences in the genetic and environmental determinants of adolescent depression
dc.contributor.author | Uddin, Monica | en_US |
dc.contributor.author | Koenen, Karestan C. | en_US |
dc.contributor.author | de los Santos, Regina | en_US |
dc.contributor.author | Bakshis, Erin | en_US |
dc.contributor.author | Aiello, Allison E. | en_US |
dc.contributor.author | Galea, Sandro | en_US |
dc.date.accessioned | 2010-08-02T17:46:59Z | |
dc.date.available | 2011-03-01T16:26:47Z | en_US |
dc.date.issued | 2010-07 | en_US |
dc.identifier.citation | Uddin, Monica; Koenen, Karestan C.; de los Santos, Regina; Bakshis, Erin; Aiello, Allison E.; Galea, Sandro (2010). "Gender differences in the genetic and environmental determinants of adolescent depression." Depression and Anxiety 27(7): 658-666. <http://hdl.handle.net/2027.42/77512> | en_US |
dc.identifier.issn | 1091-4269 | en_US |
dc.identifier.issn | 1520-6394 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77512 | |
dc.description.abstract | Background: The well-documented gender differences in the risk for depression may be explained by genetic factors, by different responses to social context, or by a combination of both. We sought to assess whether there were gender differences in the longitudinal associations between serotonin transporter promoter ( 5-HTTLPR ) genotype and depressive symptoms in adolescents, and whether macrosocial context plays a role in explaining any observed differences. Methods: Using data from a nationally representative survey of adolescents, we applied multilevel mixed models to assess, separately for adolescent males and females (a) the relation between 5-HTTLPR genotype and depressive symptoms and (b) the interaction of county-level deprivation and 5- HTTLPR genotype in models predicting depressive symptoms. All models adjusted for age and other covariates. Results: Among females ( n =560), main effects models showed an association between the sl genotype and lowered risk of depressive symptoms ( b =−.18, P =.03). Among males ( n =524), interaction models showed an association between sl genotype and lowered risk of depressive symptoms in deprived counties only ( b =−.32, P =.04). Conclusions: In adolescent females, the 5-HTTLPR sl genotype confers protection against depressive symptoms independent of county-level social context, whereas in adolescent males, protection by the same genotype is conferred only within the context of county-level deprivation. Future work should aim to understand how genetic and macrosocial factors jointly shape risk for mental illness, and how these factors shape gender differences in mental illness. Depression and Anxiety, 2010.© 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 154029 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Gender differences in the genetic and environmental determinants of adolescent depression | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan ; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029 | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Departments of Society, Human Development, and Health and Epidemiology, Harvard School of Public Health, Cambridge, Massachusetts | en_US |
dc.contributor.affiliationother | Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York | en_US |
dc.identifier.pmid | 20336806 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77512/1/20692_ftp.pdf | |
dc.identifier.doi | 10.1002/da.20692 | en_US |
dc.identifier.source | Depression and Anxiety | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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