The loudness dependence auditory evoked potential is insensitive to acute changes in serotonergic and noradrenergic neurotransmission
dc.contributor.author | Oliva, Jessica | en_US |
dc.contributor.author | Leung, Sumie | en_US |
dc.contributor.author | Croft, Rodney J. | en_US |
dc.contributor.author | O'Neill, Barry V. | en_US |
dc.contributor.author | O'Kane, Joanne | en_US |
dc.contributor.author | Stout, Julie | en_US |
dc.contributor.author | Phan, K. Luan | en_US |
dc.contributor.author | Nathan, Pradeep J. | en_US |
dc.date.accessioned | 2010-08-02T17:48:30Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-07 | en_US |
dc.identifier.citation | Oliva, Jessica; Leung, Sumie; Croft, Rodney J.; O'Neill, Barry V.; O'Kane, Joanne; Stout, Julie; Phan, K. Luan; Nathan, Pradeep J. (2010). "The loudness dependence auditory evoked potential is insensitive to acute changes in serotonergic and noradrenergic neurotransmission." Human Psychopharmacology: Clinical and Experimental 25(5): 423-427. <http://hdl.handle.net/2027.42/77527> | en_US |
dc.identifier.issn | 0885-6222 | en_US |
dc.identifier.issn | 1099-1077 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77527 | |
dc.description.abstract | Background The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as an electrophysiological marker for assessing serotonergic function in vivo in humans, although accumulating evidence suggests that it is insensitive to acute changes in serotonergic neurotransmission. Very little is known about the sensitivity of the LDAEP to other neurotransmitter systems including the noradrenergic system. The current study examined the effects of noradrenergic modulation as well as serotonergic modulation on the LDAEP. Methods The study utilised a double-blind placebo-controlled design in which the LDAEP in 17 healthy males and females was tested following acute administration of each of citalopram (20 mg), reboxetine (4 mg) and placebo. Results Neither citalopram nor reboxetine modulated the LDAEP relative to placebo treatment ( p > 0.05). Conclusion These findings suggest that the LDAEP is insensitive to acute changes in serotonergic or noradrenergic neurotransmission and thus is a poor pharmacodynamic marker of these systems. Copyright © 2010 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 116625 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | The loudness dependence auditory evoked potential is insensitive to acute changes in serotonergic and noradrenergic neurotransmission | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | School of Psychology and Psychiatry, Monash University, Melbourne, VIC, Australia | en_US |
dc.contributor.affiliationother | Brain Sciences Institute, Swinburne University of Technology, Melbourne, VIC, Australia | en_US |
dc.contributor.affiliationother | School of Psychology, University of Wollongong, Wollongong, NSW, Australia | en_US |
dc.contributor.affiliationother | Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK | en_US |
dc.contributor.affiliationother | Brain Sciences Institute, Swinburne University of Technology, Melbourne, VIC, Australia | en_US |
dc.contributor.affiliationother | School of Psychology and Psychiatry, Monash University, Melbourne, VIC, Australia | en_US |
dc.contributor.affiliationother | School of Psychology and Psychiatry, Monash University, Melbourne, VIC, Australia ; Clinical Unit Cambridge, GlaxoSmithKline Pharmaceuticals, Cambridge, UK ; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. | en_US |
dc.identifier.pmid | 20589921 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77527/1/1133_ftp.pdf | |
dc.identifier.doi | 10.1002/hup.1133 | en_US |
dc.identifier.source | Human Psychopharmacology: Clinical and Experimental | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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