Initial lymphocyte count and the development of persistent/chronic immune thrombocytopenic purpura
dc.contributor.author | Ahmed, Ibrahim | en_US |
dc.contributor.author | Rajpurkar, Madhvi | en_US |
dc.contributor.author | Thomas, Ronald | en_US |
dc.contributor.author | Chitlur, Meera B. | en_US |
dc.date.accessioned | 2010-08-02T17:48:47Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-09 | en_US |
dc.identifier.citation | Ahmed, Ibrahim; Rajpurkar, Madhvi; Thomas, Ronald; Chitlur, Meera (2010). "Initial lymphocyte count and the development of persistent/chronic immune thrombocytopenic purpura." Pediatric Blood & Cancer 55(3): 508-511. <http://hdl.handle.net/2027.42/77530> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77530 | |
dc.description.abstract | Background Acute immune thrombocytopenic purpura (ITP) is a common, benign, self-limiting disease in children. Chronic ITP is diagnosed when thorombocytopenia persists beyond 12 months. Older age is associated with increased risk for development of chronic ITP. The main objective of the current study was to examine whether total leukocyte (TLC) and absolute lymphocyte counts (ALC) at diagnosis correlate with the persistence of ITP beyond 6 months. Procedure Two hundred and twenty four consecutive medical records for patients diagnosed with immune thrombocytopenia, between April 1993 and July 2007, were reviewed and 188 patients were eligible for analysis. Case records were examined to ascertain the following information: age, gender, ethnicity, date of presentation, presenting CBC with differential count, treatment given and the outcome. Results The male to female ratio was almost 1:1; 24% (45/188) of patients had persistent ITP beyond 6 months. We determined that age >8.5 year, TLC < 6,250/µl and ALC < 3,050/µl was associated with a significant risk for development of persistent ITP beyond 6 months. Conclusions TLC and ALC at diagnosis are predictive variables for the development of persistent/chronic ITP. Further studies are recommended to confirm the current finding and to assess the underlying pathophysiology with the course of the ITP. Pediatr Blood Cancer. 2010;55:508–511. © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 120514 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Initial lymphocyte count and the development of persistent/chronic immune thrombocytopenic purpura | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | The Carman and Ann Adams Department of Pediatrics, Pediatric Hematology/Oncology Division, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan ; Pediatric Oncology Division, National Cancer Institute, Cairo University, Cairo, Egypt ; Pediatric Oncology Division, National Cancer Institute, Cairo University, Foum El-Khalig, Kasr Al-Aini, Cairo, Egypt. | en_US |
dc.contributor.affiliationother | The Carman and Ann Adams Department of Pediatrics, Pediatric Hematology/Oncology Division, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Children's Research Center of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | The Carman and Ann Adams Department of Pediatrics, Pediatric Hematology/Oncology Division, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan ; Children's Hospital of Michigan, Pediatric Hematology Oncology Division, 3901 Beaubien Blvd, Detroit, MI 48201. | en_US |
dc.identifier.pmid | 20658623 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77530/1/22570_ftp.pdf | |
dc.identifier.doi | 10.1002/pbc.22570 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.