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Fully automated, high yielding production of N -succinimidyl 4-[ 18 F]fluorobenzoate ([ 18 F]SFB), and its use in microwave-enhanced radiochemical coupling reactions

dc.contributor.authorScott, Peter J. H.en_US
dc.contributor.authorShao, Xiaen_US
dc.date.accessioned2010-09-02T15:23:43Z
dc.date.available2011-03-01T16:26:46Zen_US
dc.date.issued2010-07en_US
dc.identifier.citationScott, Peter J. H.; Shao, Xia (2010). "Fully automated, high yielding production of N -succinimidyl 4-[ 18 F]fluorobenzoate ([ 18 F]SFB), and its use in microwave-enhanced radiochemical coupling reactions." Journal of Labelled Compounds and Radiopharmaceuticals 53(9): 586-591. <http://hdl.handle.net/2027.42/77974>en_US
dc.identifier.issn0362-4803en_US
dc.identifier.issn1099-1344en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/77974
dc.description.abstractA General Electric Medical Systems (GEMS) Tracerlab FX FN fluorine-18 synthesis module has been reconfigured to allow rapid (45 min), fully automated production of N -succinimidyl 4-[ 18 F]fluorobenzoate ([ 18 F]SFB) using the established three-step, one-pot synthesis procedure. Purification is by sep-pak only and [ 18 F]SFB is routinely obtained in 38% non-decay corrected yield,>1 Ci/µmol specific activity, and >95% radiochemical purity ( n =20). Moreover, this report includes our preliminary research efforts into improving peptide coupling reactions with [ 18 F]SFB using microwave-enhanced radiochemistry. Reaction times can be reduced by>90%, when compared with traditional thermal reactions, with no significant effect on radiochemical reaction yield. Copyright © 2010 John Wiley & Sons, Ltd.en_US
dc.format.extent256125 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherJohn Wiley & Sons, Ltd.en_US
dc.subject.otherChemistryen_US
dc.subject.otherFood Science, Agricultural, Medicinal and Pharmaceutical Chemistryen_US
dc.titleFully automated, high yielding production of N -succinimidyl 4-[ 18 F]fluorobenzoate ([ 18 F]SFB), and its use in microwave-enhanced radiochemical coupling reactionsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelRadiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumUniversity of Michigan Medical School, Ann Arbor, MI, USA ; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/77974/1/1785_ftp.pdf
dc.identifier.doi10.1002/jlcr.1785en_US
dc.identifier.sourceJournal of Labelled Compounds and Radiopharmaceuticalsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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