Characterization of skeletal muscle effects associated with daptomycin in rats
dc.contributor.author | Kostrominova, Tatiana Y. | en_US |
dc.contributor.author | Hassett, Cheryl A. | en_US |
dc.contributor.author | Rader, Erik P. | en_US |
dc.contributor.author | Davis, Carol A. | en_US |
dc.contributor.author | Larkin, Lisa M. | en_US |
dc.contributor.author | Coleman, Scott | en_US |
dc.contributor.author | Oleson, Frederick B. | en_US |
dc.contributor.author | Faulkner, John A. | en_US |
dc.date.accessioned | 2010-09-02T15:24:09Z | |
dc.date.available | 2011-03-01T16:26:46Z | en_US |
dc.date.issued | 2010-09 | en_US |
dc.identifier.citation | Kostrominova, Tatiana Y.; Hassett, Cheryl A.; Rader, Erik P.; Davis, Carol; Larkin, Lisa M.; Coleman, Scott; Oleson, Frederick B.; Faulkner, John A. (2010). "Characterization of skeletal muscle effects associated with daptomycin in rats." Muscle & Nerve 42(3): 385-393. <http://hdl.handle.net/2027.42/77978> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77978 | |
dc.description.abstract | Daptomycin is a lipopeptide antibiotic with strong bactericidal effects against Gram-positive bacteria and minor side effects on skeletal muscles. The type and magnitude of the early effect of daptomycin on skeletal muscles of rats was quantified by histopathology, examination of contractile properties, Evans Blue Dye uptake, and effect on the patch repair process. A single dose of daptomycin of up to 200 mg/kg had no effect on muscle fibers. A dose of 150 mg/kg of daptomycin, twice per day for 3 days, produced a small number of myofibers (≤0.22%) with loss of plasma membrane integrity and/or infiltration by neutrophils and/or macrophages. Multiple doses of daptomycin are required for a quantifiable effect on skeletal muscles of rats. Some fibers were Evans Blue Dye–positive but were not yet infiltrated by neutrophils. This suggests that the sarcolemma may be the primary target for the observed effects. Muscle Nerve, 2010 | en_US |
dc.format.extent | 633768 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Characterization of skeletal muscle effects associated with daptomycin in rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA ; Department of Anatomy and Cell Biology, Indiana University School of Medicine–Northwest, Gary, Indiana 46409-1008, USA ; Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Cubist Pharmaceuticals, Lexington, Massachusetts, USA | en_US |
dc.contributor.affiliationother | Cubist Pharmaceuticals, Lexington, Massachusetts, USA | en_US |
dc.identifier.pmid | 20544940 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77978/1/21691_ftp.pdf | |
dc.identifier.doi | 10.1002/mus.21691 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.