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Regular Tart Cherry Intake Alters Abdominal Adiposity, Adipose Gene Transcription, and Inflammation in Obesity-Prone Rats Fed a High Fat Diet

dc.contributor.authorSeymour, E. Mitchellen_US
dc.contributor.authorLewis, Sarah K.en_US
dc.contributor.authorUrcuyo-Llanes, Daniel E.en_US
dc.contributor.authorTanone, Ignasia I.en_US
dc.contributor.authorKirakosyan, Araen_US
dc.contributor.authorKaufman, Peter B.en_US
dc.contributor.authorBolling, Steven F.en_US
dc.date.accessioned2010-10-14T14:18:24Z
dc.date.available2010-10-14T14:18:24Z
dc.date.issued2009-10en_US
dc.identifier.citationSeymour, E.M.; Lewis, Sarah K.; Urcuyo-Llanes, Daniel E.; Tanone, Ignasia I.; Kirakosyan, Ara; Kaufman, Peter B.; Bolling, Steven F. (2009/10). "Regular Tart Cherry Intake Alters Abdominal Adiposity, Adipose Gene Transcription, and Inflammation in Obesity-Prone Rats Fed a High Fat Diet." Journal of Medicinal Food, 12(5): 935-942 <http://hdl.handle.net/2027.42/78120>en_US
dc.identifier.issn1096-620Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/78120
dc.description.abstractAbstract Obesity, systemic inflammation, and hyperlipidemia are among the components of metabolic syndrome, a spectrum of phenotypes that can precede the development of type 2 diabetes and cardiovascular disease. Animal studies show that intake of anthocyanin-rich extracts can affect these phenotypes. Anthocyanins can alter the activity of tissue peroxisome proliferator-activated receptors (PPARs), which affect energy substrate metabolism and inflammation. However, it is unknown if physiologically relevant, anthocyanin-containing whole foods confer similar effects to concentrated, anthocyanin extracts. The effect of anthocyanin-rich tart cherries was tested in the Zucker fatty rat model of obesity and metabolic syndrome. For 90 days, rats were pair-fed a higher fat diet supplemented with either 1% (wt/wt) freeze-dried, whole tart cherry powder or with a calorie- and macronutrient-matched control diet. Tart cherry intake was associated with reduced hyperlipidemia, percentage fat mass, abdominal fat (retroperitoneal) weight, retroperitoneal interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression, and plasma IL-6 and TNF-α. Tart cherry diet also increased retroperitoneal fat PPAR-α and PPAR-γ mRNA (P=.12), decreased IL-6 and TNF-α mRNA, and decreased nuclear factor κB activity. In conclusion, in at-risk obese rats fed a high fat diet, physiologically relevant tart cherry consumption reduced several phenotypes of metabolic syndrome and reduced both systemic and local inflammation. Tart cherries may reduce the degree or trajectory of metabolic syndrome, thereby reducing risk for the development of type 2 diabetes and heart disease.en_US
dc.format.extent172966 bytes
dc.format.extent3100 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMary Ann Liebert, Inc.en_US
dc.titleRegular Tart Cherry Intake Alters Abdominal Adiposity, Adipose Gene Transcription, and Inflammation in Obesity-Prone Rats Fed a High Fat Dieten_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid19857054en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78120/1/jmf.2008.0270.pdf
dc.identifier.doi10.1089/jmf.2008.0270en_US
dc.identifier.sourceJournal of Medicinal Fooden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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