CD28/B7-Mediated Co-stimulation Is Critical for Early Control of Murine Cytomegalovirus Infection
dc.contributor.author | Cook, Charles H. | en_US |
dc.contributor.author | Chen, Li | en_US |
dc.contributor.author | Wen, Jin | en_US |
dc.contributor.author | Zimmerman, Peter | en_US |
dc.contributor.author | Zhang, Yingxue | en_US |
dc.contributor.author | Trgovcich, Joanne | en_US |
dc.contributor.author | Liu, Yang | en_US |
dc.contributor.author | Gao, Jian-xin | en_US |
dc.date.accessioned | 2010-10-14T14:19:22Z | |
dc.date.available | 2010-10-14T14:19:22Z | |
dc.date.issued | 2009-04 | en_US |
dc.identifier.citation | Cook, Charles H.; Chen, Li; Wen, Jin; Zimmerman, Peter; Zhang, Yingxue; Trgovcich, Joanne; Liu, Yang; Gao, Jian-xin (2009/03/27). "CD28/B7-Mediated Co-stimulation Is Critical for Early Control of Murine Cytomegalovirus Infection." Viral Immunology, 22(2): 91-103 <http://hdl.handle.net/2027.42/78134> | en_US |
dc.identifier.issn | 0882-8245 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78134 | |
dc.description.abstract | Abstract Control of acute murine cytomegalovirus (MCMV) infection is dependent upon both innate and adaptive immune responses, relying primarily upon natural killer (NK) and T-cell responses for control. Although CD28/B7 plays a clear role in T-cell responses in many antigen systems including some viral infections, the importance of co-stimulation during MCMV infection is unconfirmed. In addition, recent data suggest that CD28/B7 co-stimulation might also be important to Ly49H+ NK-cell expansion. We therefore hypothesized that CD28/B7 co-stimulation is critical to viral control after MCMV infection, and further that CD28/B7 co-stimulation plays a role in MCMV-specific T- and NK-cell responses. To test these hypotheses, we utilized C57BL/6 mice lacking the co-stimulatory molecules B7-1 and B7-2 or CD28. After primary infection with MCMV, viral titers are significantly elevated in mice lacking CD28 or B7 compared with wild-type mice. Impaired viral control is associated with significant defects in peripheral T-cell responses to MCMV, which appear to be dependent upon CD28/B7 co-stimulation. Abnormal hepatic T-cell responses in CD28/ mice are preceded by impaired MCMV-specific Ly49H+ NK-cell responses. Cytokine evaluations confirm that CD28/B7 co-stimulation is not required for non-specific antiviral responses. We conclude that CD28-mediated co-stimulation is critical for early viral control during acute MCMV infection. | en_US |
dc.format.extent | 510606 bytes | |
dc.format.extent | 3100 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc. | en_US |
dc.title | CD28/B7-Mediated Co-stimulation Is Critical for Early Control of Murine Cytomegalovirus Infection | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 19326996 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78134/1/vim.2008.0080.pdf | |
dc.identifier.doi | 10.1089/vim.2008.0080 | en_US |
dc.identifier.source | Viral Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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