The DNA damage response—Repair or despair?
dc.contributor.author | Ljungman, Mats | en_US |
dc.date.accessioned | 2010-11-03T15:19:38Z | |
dc.date.available | 2011-03-01T16:26:46Z | en_US |
dc.date.issued | 2010-10 | en_US |
dc.identifier.citation | Ljungman, Mats (2010). "The DNA damage response—Repair or despair?." Environmental and Molecular Mutagenesis 51(8-9): 879-889. <http://hdl.handle.net/2027.42/78214> | en_US |
dc.identifier.issn | 0893-6692 | en_US |
dc.identifier.issn | 1098-2280 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78214 | |
dc.description.abstract | The term “the DNA damage response” (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair. More recent discoveries of signal transduction pathways linking DNA damage to cell cycle arrest and apoptosis have greatly expanded our views of how cells and tissues limit mutagenesis and tumorigenesis. DNA repair not only plays a pivotal role in suppressing mutagenesis but also in the reversal of signals inducing the stress response. If repair is faulty or the cell is overwhelmed by damage, chances are that the cell will despair and be removed by apoptosis. This final fate is determined by intricate cellular dosimeters that are yet to be fully understood. Here, key findings leading to our current view of DDR are discussed as well as potential areas of importance for future studies. Environ. Mol. Mutagen., 2010. © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 726667 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Occupational Health and Environmental Toxicology | en_US |
dc.title | The DNA damage response—Repair or despair? | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan ; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan ; Department of Radiation Oncology, University of Michigan, 4424C Med Sci I, 1301 Catherine Street, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 20818630 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78214/1/20597_ftp.pdf | |
dc.identifier.doi | 10.1002/em.20597 | en_US |
dc.identifier.source | Environmental and Molecular Mutagenesis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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