An alginate hydrogel dura mater replacement for use with intracortical electrodes
dc.contributor.author | Nunamaker, Elizabeth A. | en_US |
dc.contributor.author | Kipke, Daryl R. | en_US |
dc.date.accessioned | 2010-11-03T15:22:03Z | |
dc.date.available | 2011-03-01T16:26:48Z | en_US |
dc.date.issued | 2010-11 | en_US |
dc.identifier.citation | Nunamaker, Elizabeth A.; Kipke, Daryl R. (2010). "An alginate hydrogel dura mater replacement for use with intracortical electrodes." Journal of Biomedical Materials Research Part B: Applied Biomaterials 95B(2): 421-429. <http://hdl.handle.net/2027.42/78236> | en_US |
dc.identifier.issn | 1552-4973 | en_US |
dc.identifier.issn | 1552-4981 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78236 | |
dc.description.abstract | The collagenous dura mater requires a secure closure following implantation of neural prosthetic devices to avoid complications due to cerebrospinal fluid leakage and infections. Alginate was previously suggested for use as a dural sealant. The liquid application and controllable gelling conditions enable alginate to conform to the unique geometries of a neural prosthetic device and the surrounding dura mater to create a barrier with the external environment. In this study, we evaluated the use of alginate as a method to securely reclose a dural defect and seal around an untethered microscale neural probe in the rabbit model. After 3 days and 3 weeks, the sealing strength of alginate remained eight times greater than normal rabbit intracranial pressure and similar in both the presence and absence of a penetrating neural probe. For time points up to 3 months, there was no significant difference in dura mater fibrosis or thickness between alginate and controls. Application of alginate to a dural defect results in a watertight seal that remains intact while the dura mater reforms. These findings indicate that alginate is an effective tool for sealing around microscale neural probes and suggests broader application as a sealant for larger neural prosthetic devices. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010. | en_US |
dc.format.extent | 461918 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | An alginate hydrogel dura mater replacement for use with intracortical electrodes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2099 ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2099 | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2099 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78236/1/31733_ftp.pdf | |
dc.identifier.doi | 10.1002/jbm.b.31733 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part B: Applied Biomaterials | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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