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Influence of Solute Charge and Hydrophobicity on Partitioning and Diffusion in a Genetically Engineered Silk-Elastin-Like Protein Polymer Hydrogel
dc.contributor.authorDinerman, Adam A.en_US
dc.contributor.authorCappello, Josephen_US
dc.contributor.authorEl-Sayed, Mohameden_US
dc.contributor.authorHoag, Stephen W.en_US
dc.contributor.authorGhandehari, Hamidrezaen_US
dc.date.accessioned2010-11-03T15:22:29Z
dc.date.available2011-03-01T16:26:41Zen_US
dc.date.issued2010-10-08en_US
dc.identifier.citationDinerman, Adam A.; Cappello, Joseph; El-Sayed, Mohamed; Hoag, Stephen W.; Ghandehari, Hamidreza (2010). "Influence of Solute Charge and Hydrophobicity on Partitioning and Diffusion in a Genetically Engineered Silk-Elastin-Like Protein Polymer Hydrogel." Macromolecular Bioscience 10(10): 1235-1247. <http://hdl.handle.net/2027.42/78240>en_US
dc.identifier.issn1616-5187en_US
dc.identifier.issn1616-5195en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/78240
dc.description.abstractThe influence of solute hydrophobicity and charge on partitioning and diffusion in physically crosslinked networks of a genetically engineered SELP polymer was investigated. A series of fluorescent dyes were used to assess the impact of solute charge and hydrophobicity on release behavior. The mechanism of solute release from the SELP hydrogel appeared to vary as a function of dye hydrophobicity. The extent of FITC attachment to amine-terminated G4 dendrimers influenced SELP hydrogel partitioning more than dendrimer diffusion properties. Results suggest the possibility of controlling solute release from SELP hydrogels by modifying the hydrophobicity and surface charge of drugs and drug/polymer conjugates as well as the possibility of “designing-in” solute-specific interactions.en_US
dc.format.extent375409 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWILEY-VCH Verlagen_US
dc.subject.otherChemistryen_US
dc.subject.otherBiochemistry and Biotechnologyen_US
dc.titleInfluence of Solute Charge and Hydrophobicity on Partitioning and Diffusion in a Genetically Engineered Silk-Elastin-Like Protein Polymer Hydrogelen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, University of Maryland, 20 N. Pine Street, Baltimore, USA ; Current address: Department of Bioengineering, University of Michigan, 1101 Beal Ave., Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Pharmaceutical Sciences, University of Maryland, 20 N. Pine Street, Baltimore, USA ; Current address: Centocor, Inc., 145 King of Prussia Road, Radnor, PA 19087, USAen_US
dc.contributor.affiliationotherProtein Polymer Technologies, Inc., 10655 Sorrento Valley Road, San Diego, CA 92121, USAen_US
dc.contributor.affiliationotherDepartment of Pharmaceutical Sciences, University of Maryland, 20 N. Pine Street, Baltimore, USA ; Department of Pharmaceutical Sciences, University of Maryland, 20 N. Pine Street, Baltimore, USA.en_US
dc.contributor.affiliationotherDepartment of Pharmaceutical Sciences, University of Maryland, 20 N. Pine Street, Baltimore, USA ; Departments of Bioengineering and Pharmaceutics and Pharmaceutical Chemistry, Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84108, USA ; Departments of Bioengineering and Pharmaceutics and Pharmaceutical Chemistry, Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84108, USA. Fax: +1 801 585 0575en_US
dc.identifier.pmid20602417en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78240/1/1235_ftp.pdf
dc.identifier.doi10.1002/mabi.201000061en_US
dc.identifier.sourceMacromolecular Bioscienceen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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