African ancestry and higher prevalence of triple-negative breast cancer
dc.contributor.author | Stark, Azadeh | en_US |
dc.contributor.author | Kleer, Celina G. | en_US |
dc.contributor.author | Martin, Iman K. | en_US |
dc.contributor.author | Awuah, Baffour | en_US |
dc.contributor.author | Nsiah-Asare, Anthony | en_US |
dc.contributor.author | Takyi, Valerie | en_US |
dc.contributor.author | Braman, Maria | en_US |
dc.contributor.author | E. Quayson, Solomon | en_US |
dc.contributor.author | Zarbo, Richard | en_US |
dc.contributor.author | Wicha, Max S. | en_US |
dc.contributor.author | Newman, Lisa A. | en_US |
dc.date.accessioned | 2010-11-03T15:22:54Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-11-01 | en_US |
dc.identifier.citation | Stark, Azadeh; Kleer, Celina G.; Martin, Iman; Awuah, Baffour; Nsiah-Asare, Anthony; Takyi, Valerie; Braman, Maria; E. Quayson, Solomon; Zarbo, Richard; Wicha, Max; Newman, Lisa (2010). "African ancestry and higher prevalence of triple-negative breast cancer." Cancer 116(21): 4926-4932. <http://hdl.handle.net/2027.42/78243> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78243 | |
dc.description.abstract | BACKGROUND: The study of breast cancer in women with African ancestry offers the promise of identifying markers for risk assessment and treatment of triple-negative disease. METHODS: African American and white American women with invasive cancer diagnosed at the Henry Ford Health System comprised the primary study population, and Ghanaian patients diagnosed and/or treated at the Komfo Anokye Teaching Hospital in Kumasi, Ghana constituted the comparison group. Formalin-fixed, paraffin-embedded specimens were transported to the University of Michigan for histopathology confirmation, and assessment of estrogen and progesterone receptors and HER-2/ neu expression. RESULTS: The study population included 1008 white Americans, 581 African Americans, and 75 Ghanaians. Mean age at diagnosis was 48.0 years for Ghanaian, 60.8 years for African American, and 62.4 for white American cases ( P = .002). Proportions of Ghanaian, African American, and white American cases with estrogen receptor-negative tumors were 76%, 36%, and 22%, respectively ( P < .001), and proportions with triple-negative disease were 82%, 26%, and 16%, respectively ( P < .001). All Ghanaian cases were palpable, locally advanced cancers; 57 (76%) were grade 3. A total of 147 American women were diagnosed as stage III or IV; of these, 67.5% (n = 46) of African Americans and 44.6% (n = 29) of white Americans were grade 3. Among palpable, grade 3 cancers, Ghanaians had the highest prevalence of triple-negative tumors (82.2%), followed by African Americans (32.8%) and white Americans (10.2%). CONCLUSIONS: Our study demonstrates progressively increasing frequency of estrogen receptor-negative and triple-negative tumors among breast cancer patients with white American, African American, and Ghanaian/African backgrounds. This pattern indicates a need for additional investigations correlating the extent of African ancestry and high-risk breast cancer subtypes. Cancer 2010. © 2010 American Cancer Society. | en_US |
dc.format.extent | 178239 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | African ancestry and higher prevalence of triple-negative breast cancer | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan ; Breast Care Center, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan ; Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan ; Breast Care Center, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan ; Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 647-9647 ; Director, Breast Care Center, Professor, Department of Surgery, University of Michigan, 1500 E. Medical Center Drive, 3308 Cancer Center, Ann Arbor, MI 48109-0932 | en_US |
dc.contributor.affiliationother | Department of Pathology, Ford Health System, Detroit, Michigan ; Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | School of Public Health, University of Illinois, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Komfo Anokye Teaching Hospital, Kumasi, Ghana | en_US |
dc.contributor.affiliationother | Komfo Anokye Teaching Hospital, Kumasi, Ghana | en_US |
dc.contributor.affiliationother | Komfo Anokye Teaching Hospital, Kumasi, Ghana | en_US |
dc.contributor.affiliationother | Department of Pathology, Ford Health System, Detroit, Michigan | en_US |
dc.identifier.pmid | 20629078 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78243/1/25276_ftp.pdf | |
dc.identifier.doi | 10.1002/cncr.25276 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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