Molecular characterization of the endoplasmic reticulum: Insights from proteomic studies
dc.contributor.author | Chen, Xuequn | en_US |
dc.contributor.author | Karnovsky, Alla | en_US |
dc.contributor.author | Sans, Maria Dolors | en_US |
dc.contributor.author | Andrews, Philip C. | en_US |
dc.contributor.author | Williams, John A. | en_US |
dc.date.accessioned | 2010-11-18T20:26:56Z | |
dc.date.available | 2011-03-01T16:26:45Z | en_US |
dc.date.issued | 2010-11 | en_US |
dc.identifier.citation | Chen, Xuequn; Karnovsky, Alla; Sans, Maria Dolors; Andrews, Philip C.; Williams, John A. (2010). "Molecular characterization of the endoplasmic reticulum: Insights from proteomic studies." PROTEOMICS 10(22): 4040-4052. <http://hdl.handle.net/2027.42/78298> | en_US |
dc.identifier.issn | 1615-9853 | en_US |
dc.identifier.issn | 1615-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78298 | |
dc.description.abstract | The endoplasmic reticulum (ER) is a multifunctional intracellular organelle responsible for the synthesis, processing and trafficking of a wide variety of proteins essential for cell growth and survival. Therefore, comprehensive characterization of the ER proteome is of great importance to the understanding of its functions and has been actively pursued in the past decade by scientists in the proteomics field. This review summarizes major proteomic studies published in the past decade that focused on the ER proteome. We evaluate the data sets obtained from two different organs, liver and pancreas each of which contains a primary cell type (hepatocyte and acinar cell) with specialized functions. We also discuss how the nature of the proteins uncovered is related to the methods of organelle purification, organelle purity and the techniques used for protein separation prior to MS. In addition, this review also puts emphasis on the biological insights gained from these studies regarding the molecular functions of the ER including protein synthesis and translocation, protein folding and quality control, ER-associated degradation and ER stress, ER export and membrane trafficking, calcium homeostasis and detoxification and drug metabolism. | en_US |
dc.format.extent | 318386 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.title | Molecular characterization of the endoplasmic reticulum: Insights from proteomic studies | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI, USA ; Department of Physiology, Wayne State University, 5215 Scott Hall, Detroit, MI 48201, USA Fax: +1-313-577-5494 | en_US |
dc.contributor.affiliationum | Center for Computational Medicine and Biology, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Center for Computational Medicine and Biology, The University of Michigan, Ann Arbor, MI, USA ; Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI, USA ; Center for Computational Medicine and Biology, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 21080494 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78298/1/4040_ftp.pdf | |
dc.identifier.doi | 10.1002/pmic.201000234 | en_US |
dc.identifier.source | PROTEOMICS | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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