Delays in diagnosis and bladder cancer mortality
dc.contributor.author | Hollenbeck, Brent K. | en_US |
dc.contributor.author | Dunn, Rodney L. | en_US |
dc.contributor.author | Ye, Zaojun | en_US |
dc.contributor.author | Hollingsworth, John M. | en_US |
dc.contributor.author | Skolarus, Ted A. | en_US |
dc.contributor.author | Kim, Simon P. | en_US |
dc.contributor.author | Montie, James E. | en_US |
dc.contributor.author | Lee, Cheryl T. | en_US |
dc.contributor.author | Wood, David P. | en_US |
dc.contributor.author | Miller, David C. | en_US |
dc.date.accessioned | 2010-11-18T20:27:33Z | |
dc.date.available | 2011-03-01T16:26:46Z | en_US |
dc.date.issued | 2010-11-15 | en_US |
dc.identifier.citation | Hollenbeck, Brent K.; Dunn, Rodney L.; Ye, Zaojun; Hollingsworth, John M.; Skolarus, Ted A.; Kim, Simon P.; Montie, James E.; Lee, Cheryl T.; Wood, David P.; Miller, David C. (2010). "Delays in diagnosis and bladder cancer mortality See editorial on pages 5122-5, this issue. ." Cancer 116(22): 5235-5242. <http://hdl.handle.net/2027.42/78303> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78303 | |
dc.description.abstract | BACKGROUND: Mortality from invasive bladder cancer is common, even with high-quality care. Thus, the best opportunities to improve outcomes may precede the diagnosis. Although screening currently is not recommended, better medical care of patients who are at risk (ie, those with hematuria) has the potential to improve outcomes. METHODS: The authors used the Surveillance, Epidemiology, and End Results-Medicare linked database for the years 1992 through 2002 to identify 29,740 patients who had hematuria in the year before a bladder cancer diagnosis and grouped them according to the interval between their first claim for hematuria and their bladder cancer diagnosis. Cox proportional hazards models were fitted to assess relations between these intervals and bladder cancer mortality, adjusting first for patient demographics and then for disease severity. Adjusted logistic models were used to estimate the patient's probability of receiving a major intervention. RESULTS: Patients (n = 2084) who had a delay of 9 months were more likely to die from bladder cancer compared with patients who were diagnosed within 3 months (adjusted hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.20-1.50). This risk was not markedly attenuated after adjusting for disease stage and tumor grade (adjusted HR, 1.29; 95% CI, 1.14-1.45). In fact, the effect was strongest among patients who had low-grade tumors (adjusted HR, 2.11; 95% CI, 1.69-2.64) and low-stage disease (ie, a tumor [T] classification of Ta or tumor in situ; adjusted HR, 2.02; 95% CI, 1.54-2.64). CONCLUSIONS: A delay in the diagnosis of bladder cancer increased the risk of death from disease independent of tumor grade and or disease stage. Understanding the mechanisms that underlie these delays may improve outcomes among patients with bladder cancer. Cancer 2010. © 2010 American Cancer Society. | en_US |
dc.format.extent | 168190 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Delays in diagnosis and bladder cancer mortality | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Urology, Division of Oncology, University of Michigan Health System, Ann Arbor, Michigan ; Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan ; The Michigan Surgical Collaborative for Outcomes Research and Evaluation, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 936-9127 ; Department of Urology, University of Michigan Health System, 1500 East Medical Center Drive, TC 3875, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan ; Robert Wood Johnson Clinical Scholars Program, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Division of Oncology, University of Michigan Health System, Ann Arbor, Michigan ; Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Division of Oncology, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Division of Oncology, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, Division of Oncology, University of Michigan Health System, Ann Arbor, Michigan ; Department of Urology, Dow Division of Health Services Research, University of Michigan Health System, Ann Arbor, Michigan ; The Michigan Surgical Collaborative for Outcomes Research and Evaluation, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 20665490 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78303/1/25310_ftp.pdf | |
dc.identifier.doi | 10.1002/cncr.25310 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.