Now showing items 11-20 of 29
Anticonvulsant activity of cyclopentano amino acids
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1980-01)
The hypothesis that certain amino acid analogues possessing a five-membered ring structure or amino acid analogues that can be viewed as fragments derived from such a ring would have anticonvulsant activity was proposed ...
Expression of Corticotropin-Releasing Hormone Transgenes in Neurons of Adult and Developing Mice
(Elsevier, 1994-12)
The DNA sequences important for cell-specific expression and developmental regulation of corticotropin-releasing hormone (CRH) were analyzed in transgenic mice. A construct containing 0.5 kb of CRH 5' flanking DNA linked ...
Age-dependent changes in the specificity of tRNA methyltransferases in the cerebellum of the icteric and nonicteric Gunn rat
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1979-10)
The activity of tRNA methyltransferases present in the cerebellum of 6- and 21-day-old nonicteric and icteric Gunn rats was compared using purified E. coli tRNAs as substrates. At 6 days the tRNA methyltransferases of the ...
Protein Kinase Inhibitors Block Neurite Outgrowth from Explants of Goldfish Retina
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1997-10)
A role for protein phosphorylation in the process of neurite outgrowth has been inferred from many studies of the effects of protein kinase inhibitors and activators on cultured neurotumor cells and primary neuronal cells ...
Isolation and expression of the Drosophila drosulfakinin neural peptide gene product, DSK-I
(Elsevier, 1992-08)
The Drosophila drosulfakinin (dsk) gene encodes the cholecystokinin homologues drosulfakinin-I (DSK-I) and drosulfakinin-II (DSK-II). The naturally occurring DSKI peptide was isolated from an extract of adult flies and its ...
William Hogarth, Unwitting Neurochemist?
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-10)
William Hogarth's famous etching Gin Lane is often used to illustrate the debilitating results of alcohol addiction. Less well known is the companion etching Beer Street in which death, murder and squalor are replaced by ...
Residual effects of tracer in sequential double label deoxyglucose studies
(Elsevier, 1992-11-23)
The validity of sequential double label deoxyglucose (DG) determinations of local metabolic rate for glucose (IMRglc) was examined by quantifying the degree of trapping of residual first DG tracer during the second ...
Studies on the localization of newly added membrane in growing neurites
(Wiley Subscription Services, Inc., A Wiley Company, 1981-11)
Explant culture of the adult goldfish retina results in vigorous neuritic growth, provided that the optic nerve has been previously crushed in vivo. The site of new membrane addition in these growing neurites was studied ...
Induction of α1-tubulin gene expression during development and regeneration of the fish central nervous system
(John Wiley & Sons, Inc., 1998-11-15)
The α1- and α2-tubulin encoding genes were cloned from a goldfish genomic DNA library. α1- and α2-tubulin RNA expression was examined in developing and adult retinas. These studies demonstrated increased α1-tubulin RNA in ...
The retina as a biochemical model of central nervous system regeneration
(Elsevier, 1980)
The visual system of primitive vertebrates has long served as a useful model for the resynthesis of damaged neurons. The prior optic nerve crush imparts a marked tendency on the part of cultured retinal explants to extend ...