Now showing items 1-10 of 11
Opposing roles of FoxP1 and Nfat3 in transcriptional control of cardiomyocyte hypertrophy, Supplemental material
(2011-06-15)
Cardiac homeostasis is maintained by a balance of growth-promoting and growth-modulating factors. Sustained elevation of calcium signaling can induce cardiac hypertrophy through activation of Nfat family transcription ...
Computational Design of Peptides to Block Binding of the SARS-CoV-2 Spike Protein to Human ACE2
(2020-03-31)
The outbreak of COVID-19 has now become a global pandemic and it continues to spread rapidly worldwide, severely threatening lives and economic stability. Making the problem worse, there is no specific antiviral drug that ...
Cycling of Etk and Etp Phosphorylation States Is Involved in Formation of Group 4 Capsule by Escherichia coli
(Public Library of Science, 2012)
Capsules frequently play a key role in bacterial interactions with their environment. Escherichia coli capsules were categorized as groups 1 through 4, each produced by a distinct mechanism. Etk and Etp are members of ...
Structure, Mechanism and Regulation of Homocitrate Synthase.
(2010)
The amino acid lysine is synthesized via two distinct pathways with the alpha-aminoadipate (AAA) pathway being utilized by fungi and certain archaebacteria. The first and committed step of this pathway is catalyzed by ...
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
(2010-11-01)
Abstract Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment. ...
High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines
(2020-07-07)
Li et al. develop an automatic preprocessing workflow for single-particle cryo-EM. This workflow produces high-resolution particle stacks from micrograph inputs without subjective decision making. They used this workflow ...