Now showing items 41-50 of 171
Certain 8-amino-9-(benzyl)guanines as potential purine nucleoside phosphorylase inhibitors
(Elsevier, 1994)
Several 8-amino-9-(benzyl)guanines were selected for synthesis as potential purine nucleoside phosphorylase (PNP) inhibitors on the basis of the Topliss decision tree. These compounds were prepared by the treatment of ...
Optical errors in a liquid chromatography absorbance cell
(Elsevier, 1988)
The shadowgraph method is used to visualize mobile phase flow through a liquid chromatography absorbance cell with "Z" flow geometry. It is shown thatmixing is incomplete in the cell. Composition gradients persist throughout ...
Interaction of , -erythro- and ,-threo-[gamma]-fluoromethotrexate with human leukemia cell dihydrofolate reductase
(Elsevier, 1989-12-01)
Gamma-fluoromethotrexate (FMTX) is a poorly glutamylated mimic of the anti-cancer drug methotrexate (MTX) which is useful in studies of the roles of MTX poly-[gamma]-glutamates. A second chiral center occurs at C-4 of the ...
Rapid communication : Inhibition of adenosine deaminase by azapurine ribonucleosides
(Elsevier, 1992-11-03)
We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value ...
Rotational analysis of the red electronic emission system A3[Phi] --> X3[Delta] of diatomic niobium nitride (NbN)
(Elsevier, 1988-08)
The (0,0) band of the red emission system of the diatomic molecule niobium nitride (NbN) has been rotationally analyzed and found to arise from an A3[Phi]r-X3[Delta]r transition. Constants for the two states have been ...
Synthesis of high-affinity, hydrophobic monosaccharide derivatives and study of their interaction with concanavalin A, the pea, the lentil, and fava bean lectins
(Elsevier, 1992-12)
Concanavalin A (Con A) and agglutinins from the pea (PSA), lentil (LCH), and fava bean (VFA) constitute a group of -mannose/-glucose binding legume lectins. In addition to their sugar binding specificity, these lectins ...
Fluorescence yield near edge spectroscopy of [pi]-bonded CO on Fe(100)
(Elsevier, 1989-12-03)
Near edge X-ray absorption fine structure (NEXAFS) spectra of CO adsorbed on the Fe(100) surface are reported. Spectra, obtained by fluorescence yield (FYNES), are presented for each of the four individual CO adsorption ...
The reaction of sulfur with dilithio compounds. The syntheses and structures of phenanthro [1, 10-cd]-1,2-dithiole and phenanthro[4,5-cde] [1,2]dithiin
(VCH Publishers, Inc.Wiley Periodiocals, Inc., 1994-04)
The sequential reaction of selected polycyclic aromatic hydrocarbons with butyllithium/TMEDA/hexane and sulfur allows preparation of ring-fused dithiins, dithioles, and thiophenes. In this manner, phenanthrene has been ...
Thermophysics of metal alkanoates VI. Heat capacities and thermodynamic properties of lithium n-pentanoate and n-heptanoate
(Elsevier, 1986-12)
The adiabatic calorimetric study (at 5 to 350 K) of lithium n-pentanoate and n-heptanoate proved that solid-state transitions occur at Ttrs/K = 209.31 and 319.06 in the former salt, and at Ttrs/K = 317.08 in the latter ...