Now showing items 1-10 of 65
Intravascular histiocytosis presenting with extensive vulvar necrosis
(Blackwell Publishing Ltd, 2009-10)
Cognitive-behavioral intervention for distress in patients with melanoma
(Wiley Subscription Services, Inc., A Wiley Company, 2003-08-15)
BACKGROUND Melanoma accounts for > 79% of skin cancer-related deaths, although it accounts for only 4% of skin cancer incidence. Given the potential for lethality, it is likely that patients with melanoma may experience ...
Pimecrolimus in dermatology: atopic dermatitis and beyond
(Blackwell Science Ltd, 2005-08)
Pimecrolimus is a calcineurin inhibitor developed for the topical therapy of inflammatory skin diseases, particularly atopic dermatitis (AD). Pimecrolimus selectively targets T cells and mast cells. Pimecrolimus inhibits ...
Biomedical application of immobilized enzymes
(John Wiley & Sons, Inc., 2000-08)
Reports on chemical immobilization of proteins and enzymes first appeared in the 1960s. Since then, immobilized proteins and enzymes have been widely used in the processing of variety of products and increasingly used in ...
Efficient tumour formation by single human melanoma cells
(Nature Publishing Group, 2008-12-04)
A fundamental question in cancer biology is whether cells with tumorigenic potential are common or rare within human cancers. Studies on diverse cancers, including melanoma, have indicated that only rare human cancer cells ...
WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth
(Wiley-Liss, Inc., 2008-04)
We examined the role of WNT signaling in pituitary development by characterizing the pituitary phenotype of three WNT knockout mice and assessing the expression of WNT pathway components. Wnt5a mutants have expanded ...
Repeat courses of intravenous alefacept in patients with chronic plaque psoriasis provide consistent safety and efficacy
(Blackwell Science Ltd, 2003-03)
Background Psoriasis is a chronic, relapsing skin disease that may require multiple treatment courses. Alefacept targets the memory T cells implicated in psoriasis pathogenesis. This open-label study evaluated the safety ...
Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma?
(Wiley Subscription Services, Inc., A Wiley Company, 2009-12-15)
BACKGROUND: Controversy exists as to whether patients with thick (Breslow depth >4 mm), clinically lymph node-negative melanoma require sentinel lymph node (SLN) biopsy. The authors examined the impact of SLN biopsy on ...
Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytes
(Wiley Subscription Services, Inc., A Wiley Company, 2009-08-01)
Epidermal growth factor receptor (EGFR) plays a critical role in mediating ultraviolet (UV) irradiation-induced signal transduction and gene expression in human keratinocytes. EGFR activation results from increased ...