Now showing items 1-4 of 4
GTP[gamma]S-stimulated hydrolysis of phosphatidyinositol-4,5-bisphosphate by soluble phospholipase C from human platelets requires soluble GTP-binding protein
(Elsevier, 1988-07-15)
GTP-binding activity was fractionated into two peaks (GI and GII) by chromatography on heparin-agarose. GTP-dependent PLC activity eluted as a single peak, which co-chromatographed with GTP-binding peak GII. Rechromatography ...
Differential activation of human skin cells by platelet activating factor: Stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts
(Elsevier, 1989-09-29)
Treatment of cultured adult human keratinocytes with platelet activating factor (PAF) resulted in a rapid, dose dependent accumulation of inositol phosphates. Inositol trisphosphate (IP3), inositol bisphosphate (IP2) and ...
GTP and cytosol stimulate phosphoinositide hydrolysis in isolated platelet membranes
(Elsevier, 1986-06-13)
Hydrolysis of polyphosphoinositides by phospholipase C was examined in isolated membranes prepared from [32P]labelled platelets. In the presence of GTP[gamma]S, thrombin increased the release of inositol triphosphate and ...
Increased membrane-associated transglutaminase activity in psoriasis
(Elsevier, 1989-10-16)
Terminal differentiation of human skin involves the formation of an insoluble cross-linked protein envelope (CLE), which functions as an external barrier. To characterize terminal differentiation in the skin disease ...