Now showing items 31-40 of 121
IGF receptor function and regulation in autocrine human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factor-II (IGF-II) and its receptors (type I and II IGF receptors) are expressed in the nervous system in a tissue and developmentally specific manner. We have previously shown that SH-SY5Y human ...
Kidney and Retinal Defects (Krd), a Transgene-Induced Mutation with a Deletion of Mouse Chromosome 19 That Includes the Pax2 Locus
(Elsevier, 1994-09-15)
The semidominant mutation Krd (kidney and retinal defects) was identified in transgenic line Tg8052. Krd/+ mice have a high incidence of kidney defects including aplastic, hypoplastic, and cystic kidneys. Retinal defects ...
Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat
(Elsevier, 1990-05)
The human amylase gene cluster includes a (CA)n repeat sequence immediately upstream of the [gamma]-actin pseudogene associated with the AMY2B gene. Analysis of this (CA)n repeat by PCR amplification of genomic DNA from ...
The Remarkable Evolutionary History of the Human Amylase Genes
(SAGE Publications, 1993)
Analysis of the structures of the human amylase genes has demonstrated that this multigene family contains at least five tandem gene copies, closely related in sequence but with distinct tissue specific expression. The ...
Conserved Linkage of Early Growth Response 4, Annexin 4, and Transforming Growth Factor [alpha] on Mouse Chromosome 6
(Elsevier, 1994-01-15)
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. ...
Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2
(Elsevier, 1993-01)
Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP)(PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of the human liver cDNA ...
Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20
(Elsevier, 1993-06)
The human PCK1 gene encoding phosphoenolpyruvate carboxykinase (GTP) (PEPCK) was isolated and sequenced. There is 91% amino acid sequence identity (567/622 residues) between the human and the rat proteins, with conservation ...
Genetic structure of five susceptibility gene regions for coronary artery disease: disequilibria within and among regions
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
We analyzed two-locus disequilibria for 16 polymorphic loci of seven susceptibility genes for coronary artery disease located in five chromosomal regions distributed across four chromosomes. Included were the genes coding ...
PKC Activity and PKC-[alpha] mRNA Content Are Reduced in Serum-Deprived Human Neuroblastoma Cells without Concomitant Induction of Differentiation
(Elsevier, 1993-08)
Protein kinase C (PKC) is a serine/threonine kinase which is thought to play an important role in cellular proliferation and differentiation. PKC activity is stimulated physiologically by diacylglycerol and experimentally ...