Now showing items 21-30 of 83
Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series.
(Oxford University Press (OUP), 2023-04)
Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 patients treated for B-cell malignancies with ...
Real Time Breath Analysis Using Portable Gas Chromatography for Adult Asthma Phenotypes.
(MDPI, 2021-05-01)
Asthma is heterogeneous but accessible biomarkers to distinguish relevant phenotypes remain lacking, particularly in non-Type 2 (T2)-high asthma. Moreover, common clinical character-istics in both T2-high and T2-low asthma ...
Targeting the Estrogen Receptor (ER) for the Treatment of Breast Cancer: Recent Advances and Challenges
(American Chemical Society (ACS), 2023)
Estrogen receptor alpha (ERα) is a well-established therapeutic target for the treatment of ER-positive (ER+) breast cancers. Despite the tremendous successes achieved by tamoxifen, a selective estrogen receptor modulator, ...
Teclistamab in Relapsed or Refractory Multiple Myeloma
(2022-06-23)
The MajesTEC-1 trial results reported by Professor Moreau and colleagues of the phase Ib/II clinical trial of teclistamab, an off-the-shelf novel B-cell maturation antigen (BCMA)-CD3 bispecific antibody drug in patients ...
The Rare and Atypical Diabetes Network (RADIANT) Study: Design and Early Results.
(American Diabetes Association, 2023-04-27)
OBJECTIVE: The Rare and Atypical Diabetes Network (RADIANT) will perform a study of individuals and, if deemed informative, a study of their family members with uncharacterized forms of diabetes. RESEARCH DESIGN AND METHODS: ...
Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits
(Elsevier, 2021-01-01)
Background and aims: Apolipoprotein A-II (apoAII) is the second major apolipoprotein of the high-density lipoprotein (HDL) particle, after apoAI. Unlike apoAI, the biological and physiological functions of apoAII are ...
MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits.
(Springer Nature, 2020-01-01)
Gene editing nuclease represented by Cas9 efficiently generates DNA double strand breaks at the target locus, followed by repair through either the error-prone non-homologous end joining or the homology directed repair ...
Survival motor neuron protein participates in mouse germ cell development and spermatogonium maintenance
(MDPI, 2020-02-01)
The defective human survival motor neuron 1 (SMN1) gene leads to spinal muscular atrophy (SMA), the most common genetic cause of infant mortality. We previously reported that loss of SMN results in rapid differentiation ...
CRISPR/Cas9-mediated TERT disruption in cancer cells
(MDPI, 2020-01-02)
Mammalian telomere lengths are primarily regulated by telomerase, a ribonucleoprotein consisting of a reverse transcriptase (TERT) and an RNA subunit (TERC). TERC is constitutively expressed in all cells, whereas TERT ...
Immunodeficient rabbit models: History, current status and future perspectives
(MDPI, 2020-10-02)
Production of immunodeficient (ID) models in non-murine animal species had been extremely challenging until the advent of gene-editing tools: first zinc finger nuclease (ZFN), then transcription activator-like effector ...