Now showing items 1-10 of 11
Synthesis of the Tetraketide Lactones from the Pikromycin Biosynthetic Pathway
(WILEY-VCH Verlag, 2007-07)
Synthesis of tetraketide lactones 2 and 3 , which are likely to be produced by a model pikromycin polyketide synthase (PKS), has been investigated. The tetraketide lactones with six-membered rings, 2a and 2b , were ...
Identification of the thiol residues involved in modifications of pig heart lipoamide dehydrogenase by cupric ion and by iodoacetamide
(Elsevier, 1974-11-25)
The thiol residues involved in two previously described modifications of heart lipoamide dehydrogenase (NADH:lipoamide oxidoreductase, EC 1.6.4.3) have been identified by comparison of peptide maps of unmodified and modified ...
The interaction of nitrous oxide with cobalamin-dependent methionine synthase
(Elsevier, 1991-08)
Folylpolyglutamates as substrates and inhibitors of folate-dependent enzymes
(Elsevier, 1987)
The true intracellular substrates for folate-dependent enzymes are folylpolyglutamates. We have used measurements of the Ki values of folylpolyglutamate dead end inhibitors to assess the relative affinities of folate-dependent ...
Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues
(Elsevier, 1982)
Methylenetetrahydrofolate reductase catalyzes the reduction of methylenetetrahydrofolate ot methyltetrahydrofolate. This reaction commits one carbon units to the pathways of adenosylmethionine-dependent methylation in ...
Synthetic Multivalent Ligands as Probes of Signal Transduction
(WILEY-VCH Verlag, 2006-04-03)
Cell-surface receptors acquire information from the extracellular environment and coordinate intracellular responses. Many receptors do not operate as individual entities, but rather as part of dimeric or oligomeric ...
A poke in the eye: Inhibiting HIV-1 protease through its flap-recognition pocket
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08)
A novel mechanism of inhibiting HIV-1 protease (HIVp) is presented. Using computational solvent mapping to identify complementary interactions and the Multiple Protein Structure method to incorporate protein flexibility, ...
Purification of Thermus aquaticus DNA polymerase expressed in Escherichia coli
(Elsevier, 1990-12)
DNA polymerase from Thermus aquaticus has become a common reagent in molecular biology because of its utility in DNA amplification and DNA sequencing protocols. A simplified method is described here for isolating the ...
Isolation, characterization and partial sequencing of cystine and thiol peptides of pig heart lipoamide dehydrogenase
(Elsevier, 1974-11-25)
Pig heart lipoamide dehydrogenase (EC 1.6.4.3) contains ten half-cystines (as cysteic acid) per mole of enzyme bound FAD. Two of these are linked in an intrachain cystine which acts in concert with the flavin during ...
Synthetische multivalente Liganden als Sonden fÜr die Signaltransduktion
(WILEY-VCH Verlag, 2006-04-03)
ZelloberflÄchenrezeptoren nehmen Informationen aus der extrazellulÄren Umgebung auf und stimmen die intrazellulÄren Reaktionen darauf ab. Viele dieser Rezeptoren agieren nicht einzeln, sondern als Teil von dimeren oder ...